Courtes(M),Boissière(T),Barthe(A),Pasero(P... Nucleic Acids Res 2026-04-13

...Top1-DNA crosslinks. Controlled resection, in turn, allows homologous recombination factors to access and stabilize the ...

Xie(X),Lee(J),Gi(YJ),Poullikkas(T),Fuson(J... Br J Cancer 2026-07-00

...TOP1 gene expression with poor prognosis in HR+ BC. Combining HER3-DXd with an ATR inhibitor could benefit HER3+/HR+ BC ...

Liu(A),Yang(Y),Xiang(J),Hu(Y),Yang(J),Zhan... Front Med (Lausanne) None

...TOP1 were identified as key genes. Later, the two key genes were co-enriched in multiple pathways, like "ribosome." Sign...

Lopez-Aguileta(L),Martín-Encinas(E),Knudse... Eur J Med Chem 2026-06-05

The topoisomerase I (TOP1) enzymatic inhibition was investigated using novel pyrimidine and quinazolinone derivatives. F...

Kobayashi(M),Chen(X),Honjo(T) Proc Natl Acad Sci U S A 2026-04-07

...TOP1-DNA cleavage complex (TOP1-CC) following cytidine to uridine (C-to-U) editing by AID remains undefined. To unveil t...

Takefuji(Y) Asian J Psychiatr 2026-05-00

...top1-out validation approach that systematically removes the highest-ranked feature to assess ranking stability across s...

Neppelenbroek(S),Wortel(CM),van Rijswijck(... Ann Rheum Dis 2026-08-00

...TOP1-reactive B cells. Reactivity of monoclonal and polyclonal ATAs towards TOP1 and TOP1-DNA cleavage complexes (TOP1cc...

Li(Y),Ji(D),Jia(Y),Liang(Y),Wei(E),Gao(C),... Commun Biol 2026-03-09

...TOP1) and DNA G-quadruplexes (G4s). Unlike irinotecan (CPT-11), which requires metabolic activation, ZBH-01 directly sta...

Rodriguez(A),Formoso(E),Knudsen(BR),Tesaur... ChemMedChem 2026-03-13

The topoisomerase 1 (TOP1) enzymatic inhibition and antiproliferative activity of phosphorated indenoquinoline derivativ...

Young(TM),Moumouni(R),Behl(A),Das(U),Gmein... Cancers (Basel) 2026-03-09

...Top1) cleavage complex formation; (ii) DNA double-strand breaks (DSBs), and (iii) Checkpoint Kinase 1 and 2 (p-Chk1/2) p...