Singh(S),Zhu(X),Kim(N) Int J Mol Sci 2025-09-16

...Top1Y740* mutant, analogous to the human Top1W765Stop mutant conferring resistance to CPT. We show that yTop1Y740* eleva...

Sun(W),Weng(W),Shi(J),Ma(B),D DeMarco(K),G... Bioconjug Chem 2025-10-15

...TOP1) with DNA Damage Response (DDR) inhibitors outperform single-TOP1 ADCs and free-drug combinations. SPARCs also exhi...

Sabit(H),Abbas(S),El-Safoury(MT),Madkour(E... Biomedicines 2025-09-10

...TOP1/PARP inhibitors, further underscores their synergistic potential. Despite these innovations, critical challenges re...

Zakharenko(AL),Dyrkheeva(NS),Markov(AV),Kl... Int J Mol Sci 2025-09-23

...TOP1)-DNA complexes. Previously, we obtained HEK293A cells with homozygous knockout of the TDP1 gene by the CRISPR/Cas9 ...

Heath(JR),Lloyd(AE),Kulinski(RM),Fromuth(D... J Virol 2025-09-23

...TOP1) associates with the HSV-1 genome throughout infection. TOP1 relieves topological stress on DNA to enable and regul...

Kudo(Y),Miyamoto(K),Suzuki(S),Chida(A),Toj... JCI Insight 2025-09-23

...Top1 cells declined, potentially modulating immune responses.CONCLUSIONThe study findings indicate that GLP-2 analogs re...

Wang(C),Chen(B),Yang(H),Huang(C),Zhang(Y),... J Med Chem 2025-09-25

...TOP1) inhibitors have been designed based on bioinformatics analysis results of ten tumor tissues. Among them, ZM484 sho...

Gavrilas(L),Sava(O),Balacescu(L),Miron(S),... Biochem Pharmacol 2025-12-00

...TOP1, was also inhibited. Curcumin, combined with irinotecan at IC10, reduced irinotecan's IC50 by 3.74-fold, exhibiting...

Sønderstrup(Ida Marie Heeholm),Nygård(Sune... Mol Oncol 2016-02-08

...TOP1, CEN20, TOP2A and CEN17 status was previously published for this cohort.,The observed TOP1 gene copy numbers in the...

Li(Min),Pokharel(Subhash),Wang(Jiin-Tarng)... Nat Commun 2016-04-05

...TOP1 SUMOylation by facilitating the interaction between PIAS1, SRSF1 and TOP1. Unexpectedly, the topoisomerase activity...