Venkatachalam(A),Kaufmann(SH) J Mol Biol 2026-03-01

...TOP1-directed agents, here we briefly review the biology of TOP1, the cellular effects of stabilizing TOP1-DNA covalent ...

Sayers(CM),Carter(MB),Lei(H),Mendoza(A),Sh... Cancers (Basel) 2025-07-26

...TOP1 inhibitors or for those patients who have developed resistance to TOP1 inhibitors.

Chen(G),Li(R),Tong(X),Rouzi(T),Zheng(X),Pa... Phytomedicine 2025-11-00

...TOP1) to trigger DDR. TOP1 also activates PERK/ATF4-dependent ER stress pathway, bypassing p53 signaling and inducing cy...

Lee(TH),Qiao(CX),Kuzin(V),Shi(Y),Farkas(M)... Nat Commun 2025-08-12

...TOP1) activity is essential for DNA supercoil removal, the aberrant stabilization of TOP1:DNA cleavage complexes (TOP1cc...

Khan(T),Choi(S),Rutledge(S),Seetharam(AS),... Placenta 2025-09-00

...TOP1) to distinguish STB nuclei from cytotrophoblast nuclei, and markers enriched in either cluster 5 or cluster 6, nucl...

Cheng(X),Hsia(J),Iraheta(J),Gongora(J),Hig... bioRxiv 2025-07-10

...TOP1) inhibitor payload in trastuzumab deruxtecan (T-DXd). Mechanistically, TP53 mutant tumors exhibited upregulation of...

Sun(W),Weng(W),Shi(J),Ma(B),D DeMarco(K),G... Bioconjug Chem 2025-10-15

...TOP1) with DNA Damage Response (DDR) inhibitors outperform single-TOP1 ADCs and free-drug combinations. SPARCs also exhi...

Singh(S),Zhu(X),Kim(N) Int J Mol Sci 2025-09-16

...Top1Y740* mutant, analogous to the human Top1W765Stop mutant conferring resistance to CPT. We show that yTop1Y740* eleva...

Paulin(EK),Haverkate(NA),Tomek(P),Jaiswal(... RSC Med Chem 2025-09-17

...TOP1) are particularly susceptible as cancers adopt resistance mechanisms. Drugs countering these resistance mechanisms ...

Van(TTV),Tran(TH),Nguyen(THH),Nguyen(VTC),... BMC Biol 2025-08-20

...TOP1 and MAFB. Our machine-learning model achieved an AUC of 0.90, with 93.6% specificity and 62.1-66.3% sensitivity for...