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A protein fragment derived from DNA-topoisomerase I as a novel tumour-associa...

Yie(Shang-Mian),Ye(Shang-Rong),Ma(Xiao-Li)... Br J Cancer 0000-00-00

...TOP1). We found that the novel TAA induced specific autoantibodies with a high prevalence that ranged from 58 to 72% in ...

Clinical and pharmacologic evaluation of two dosing schedules of indotecan (L...

Kummar(Shivaani),Chen(Alice),Gutierrez(Mar... Cancer Chemother Pharmacol 0000-00-00

...Top1 downregulation and γH2AX response. No objective responses were observed on either schedule in this small patient co...

Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellul...

Gao(Qiang),Wang(Zhi-Chao),Duan(Meng),Lin(Y... Gastroenterology 0000-00-00

...TOP1) were identified in intratumor subregions from 4 HCCs and were associated with sensitivity to these agents. However...

Epigenetic changes in histone acetylation underpin resistance to the topoisom...

Meisenberg(Cornelia),Ashour(Mohamed E),El-... Nucleic Acids Res 0000-00-00

...TOP1) inhibitor irinotecan triggers cell death by trapping TOP1 on DNA, generating cytotoxic protein-linked DNA breaks (...

Expression Patterns of Biomarkers in Primary Tumors and Corresponding Metasta...

Kümler(Iben),Balslev(Eva),Knop(Ann S),Brün... Appl Immunohistochem Mol Mo... 0000-00-00

...TOP1, p53, Bcl-2, and Ki-67 in 110 paired samples of primary BC and corresponding asynchronous metastases. We found disc...

Endogenous Reference Genes for Gene Expression Studies on Bicuspid Aortic Val...

Harrison(Oliver J),Moorjani(Narain),Torren... PLoS One 0000-00-00

...TOP1, UBC, YWHAZ, and 18S) using geNorm software. The most stable HK genes were found to be GAPDH, UBC and ACTB. Both GA...

Irinotecan pharmacogenetics: The influence of pharmacodynamic genes.

Hoskins(J M),Baiget(M),Marcuello(E),Altes(... J Clin Oncol 0000-00-00

...TOP1 and ADPRT variants may alter a patient's risk of experiencing neutropenia and TOP1, TDP1, ADPRT and XRCC1 variants ...

Status of topoisomerases in pediatric high grade osteosarcomas and their ther...

Entz-Werle(N),Guerin(E),Marec-Berard(P),Ta... J Clin Oncol 0000-00-00

...TOP1) was conducted on diagnostic tumors consecutively collected from this population to understand their therapeutic an...

Overexpression of a set of genes in mesothelioma versus parietal pleura may e...

Roe(O D),Anderssen(E),Helge(E),Hild Hakvaa... J Clin Oncol 0000-00-00

...TOP1, TOP2A, TYMS, BIRC5/Survivin, TUBB and 12 proteasome genes) and radio-resistance by several DNA-repair and DNA- dam...

Identification of early gene expression changes in primary cultured neurons t...

Rossi(Sharyn L),Lumpkin(Casey J),Harris(As... Biochem Biophys Res Commun 0000-00-00

Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can...

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