Tseng(Tien-Sheng),Lee(Yu-Ching),Hsiao(Nai-... Bioorg Med Chem Lett 0000-00-00

...Top1 shows poor statistical significance. This study reveals pharmacophore features of Hypo1, built by 3D-QSAR Pharmacop...

Niu(Hengyao),Potenski(Catherine J),Epshtei... Cell Cycle 0000-00-00

...Top1-induced nick with subsequent non-mutagenic gap filling. We have surveyed other helicases and nucleases for a possib...

Baranello(Laura),Kouzine(Fedor),Sanford(Su... Chromosome Res 0000-00-00

...Top1) that is functionally associated with the double helix in vivo, especially with active chromatin, and green fluores...

de Camargo(Mariana S),da Silva(Monize M),C... Metallomics 0000-00-00

...Top1). Compound 3 is the most efficient Top1 inhibitor and the inhibitory effect is enhanced upon pre-incubation with th...

Mallepally(Rajender Reddy),Putta(Venkat Re... J Fluoresc 0000-00-00

...TOP1 by using LibDock. Furthermore explore antimicrobial activity, photocleavage and in vitro cytotoxicity assay of four...

Beck(Daniel E),Reddy(P V Narasimha),Lv(Wei... J Med Chem 0000-00-00

...Top1) enzyme poisoning activity and cytotoxicity to human cancer cells. The 4-aza compounds were the most likely to yiel...

Jensen(Niels Frank),Agama(Keli),Roy(Amit),... J Exp Clin Cancer Res 0000-00-00

...TOP1 gene copy number and gene sequence, Top1 expression (mRNA and protein), Top1 enzymatic activity in the absence and ...

Dukhanina(Elena A),Portseva(Tatiana N),Pan... Cell Cycle 0000-00-00

...TOP1). We established that, firstly, the most significant increase in S100A4 gene expression has been demonstrated in th...

Lv(Peng-Cheng),Elsayed(Mohamed S A),Agama(... J Med Chem 0000-00-00

...Top1 ternary cleavage complex, affect Top1 inhibitory activity and cytotoxicity. Many of the indenoisoquinoline prodrugs...

Gokare(Prashanth),Navaraj(Arunasalam),Zhan... Oncotarget 0000-00-00

...TOP1) inhibitors. Furthermore, through combined in silico and functional screens of the Diversity Set II (NCI/NTP) chemi...