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Kauh(E A),Bjornsti(M A) Proc Natl Acad Sci U S A 1995-08-10

...top1 delta yeast cells expressing plasmid-borne wild-type DNA topoisomerase I, six dominant suppressors of camptothecin ...

Zou(J),Scocca(J R),Krag(S S) Arch Biochem Biophys 1995-04-19

...top1 and ade1.

Knab(A M),Fertala(J),Bjornsti(M A) J Biol Chem 1995-04-18

...top1 vac mutants were resistant to all of the camptothecin derivatives cytotoxic to wild-type TOP1-expressing cells. Thi...

Murakami(S),Yanagida(M),Niwa(O) Mol Gen Genet 1995-04-26

...top1+ gene (type I DNA topoisomerase) suppressed the instability of the largest circular minichromosome, whereas partial...

Fujimori(A),Harker(W G),Kohlhagen(G),Hoki(... Cancer Res 1995-04-12

...top1 cDNA from CEM/C2 identified mutations corresponding to two amino acid substitutions, Met370Thr and Asn722Ser. Asn72...

Ohtake(Y),Wickner(R B) Mol Cell Biol 1995-06-02

...top1], mak7 [rpl4A], mak8 [rpl3], mak11, and mak16) had decreased free 60S subunits. Mutants with another three mak muta...

Bjornsti(M A),Knab(A M),Benedetti(P) Cancer Chemother Pharmacol 1994-09-29

...TOP1 yeast cells can be restored by plasmids expressing either yeast or human TOP1 sequences. This genetically tractable...

Asimakopoulos(F A),White(N J),Nacheva(E),G... Blood 1994-11-29

...TOP1, SEMG1, and PPGB. Several candidate tumor suppressor genes lie outside the common deleted region including SRC, HCK...

Romig(H),Ruff(J),Fackelmayer(F O),Patil(M ... Eur J Biochem 1994-06-02

...TOP1). These intronic MAR elements, designated MI and MII, are specifically bound by the nuclear matrix and partition wi...

Leteurtre(F),Fujimori(A),Tanizawa(A),Chhab... J Biol Chem 1994-12-19

...top1 and top2) inhibitors. Using saintopin (STP), a poison of both topoisomerases, we studied top1- and top2-cleavable c...