Megonigal(M D),Fertala(J),Bjornsti(M A) J Biol Chem 1997-06-16

...top1T722A expression increased rDNA recombination. In checkpoint proficient cells, pGAL1-induced top1 expression coincid...

Hoki(Y),Fujimori(A),Pommier(Y) Cancer Chemother Pharmacol 1997-09-10

...top1) and are active in cancer patients against a variety of refractory solid tumors and leukemia.,The present study fur...

Jiang(W),Gerhold(D),Kmiec(E B),Hauser(M),B... Microbiology 1997-03-31

...TOP1 was deleted and the other copy of TOP1 was placed under a regulatable promoter. Under repressed conditions, cells g...

Taylor(A),Giles(K),Sarthy(A V),McGonigal(T... FEMS Microbiol Lett 1997-02-19

...TOP1) was isolated from Candida albicans, sequenced, and expressed in Saccharomyces cerevisiae. The TOP1 gene was identi...

Beidler(D R),Chang(J Y),Zhou(B S),Cheng(Y ... Cancer Res 1996-02-13

...TOP1 interactions. Therefore, CPT resistance in the 100 and 300 lines was characterized by factors independent of TOP1, ...

Hanai(R),Caron(P R),Wang(J C) Proc Natl Acad Sci U S A 1996-06-18

...top1 cells lacking endogenous DNA topoisomerase I yielded an activity in cell extracts that specifically reduces the num...

Zhu(J),Schiestl(R H) Mol Cell Biol 1996-07-29

...TOP1 wild-type strain and at a significantly lower frequency in the top1delta strain. Our results provide in vivo eviden...

Sadoff(B U),Heath-Pagliuso(S),Castaño(I B)... Genetics 1996-07-23

...top1 null mutation are viable and display no gross defects in DNA or RNA synthesis, possibly because other proteins prov...

Goldwasser(F),Shimizu(T),Jackman(J),Hoki(Y... Cancer Res 1996-11-21

...top1 levels and differential sensitivity to CPT were studied. No difference in the kinetics of top1-mediated DNA single-...

Castaño(I B),Heath-Pagliuso(S),Sadoff(B U)... Nucleic Acids Res 1996-09-09

...top1). Here we describe the isolation of a second member of the TRF4 gene family, TRF5. Overexpression of TRF5 complemen...