Fan(Y),Weinstein(J N),Kohn(K W),Shi(L M),P... J Med Chem 1998-07-09

...top1 covalently links to the 3' terminal base, T, of the cleaved DNA strand; and (vii) top1 mutation Asn722Ser leads to ...

Park(H),Sternglanz(R) Chromosoma 1998-09-15

...top1-top2ts and top1-hpr1 mutants. Moreover, an in vitro assay showed that some topoisomerase I enzymatic activity was r...

Brown(S D),Zhang(C X),Chen(A D),Hsieh(T S) Gene 1998-07-14

...top1) has been determined. Structurally, top1 consists of eight exons and seven introns. The top1 coding region contains...

Van Dross(R T),Rao(K V),Eisenberg(E),Sande... Gene 1998-01-26

The topoisomerase I (TOP1) gene was cloned and sequenced from Aspergillus nidulans using the polymerase chain reaction (...

Hann(C),Evans(D L),Fertala(J),Benedetti(P)... J Biol Chem 1998-05-07

...Top1p yet did not appreciably increase the cytotoxic response of cells expressing a catalytically inactive (eSctop1Y727F...

Chourpa(I),Riou(J F),Millot(J M),Pommier(Y... Biochemistry 1998-06-22

...top1), have been compared. DNA was modeled using three types of double-strand oligonucleotides corresponding to top1 cle...

Hann(C L),Carlberg(A L),Bjornsti(M A) J Biol Chem 1998-12-21

...top1C273Y,T722A, top1G295V,T722A, and top1G369D,T722A, revealed this was accomplished via a mechanism of reduced affinit...

Fujimori(A),Gupta(M),Hoki(Y),Pommier(Y) Mol Pharmacol 1997-01-23

...top1 parameters such as top1 protein, RNA levels, and DNA relaxation were also similar in both cell lines. Thus, CPT res...

Jiang(W),Gerhold(D),Kmiec(E B),Hauser(M),B... Microbiology 1997-03-31

...TOP1 was deleted and the other copy of TOP1 was placed under a regulatable promoter. Under repressed conditions, cells g...

Taylor(A),Giles(K),Sarthy(A V),McGonigal(T... FEMS Microbiol Lett 1997-02-19

...TOP1) was isolated from Candida albicans, sequenced, and expressed in Saccharomyces cerevisiae. The TOP1 gene was identi...