Kohlhagen(G),Paull(K D),Cushman(M),Nagafuj... Mol Pharmacol 1998-08-06

NSC 314622 was found to have a cytotoxicity profile comparable to the topoisomerase I (top1) inhibitors camptothecin (CP...

Fan(Y),Weinstein(J N),Kohn(K W),Shi(L M),P... J Med Chem 1998-07-09

...top1 covalently links to the 3' terminal base, T, of the cleaved DNA strand; and (vii) top1 mutation Asn722Ser leads to ...

Shaiu(W L),Hsieh(T S) Mol Cell Biol 1998-07-16

...top1-lacZ transgenes. There was at least one putative nuclear localization signal within the first 315 residues of the N...

Hann(C L),Carlberg(A L),Bjornsti(M A) J Biol Chem 1998-12-21

...top1C273Y,T722A, top1G295V,T722A, and top1G369D,T722A, revealed this was accomplished via a mechanism of reduced affinit...

Haluska(P),Rubin(E H) Adv Enzyme Regul 1998-12-18

...top1. Binding of top1 by helicases may be important in the management of structural alterations in DNA produced by helic...

Park(H),Sternglanz(R) Chromosoma 1998-09-15

...top1-top2ts and top1-hpr1 mutants. Moreover, an in vitro assay showed that some topoisomerase I enzymatic activity was r...

Nitiss(J L),Zhou(J),Rose(A),Hsiung(Y),Gale... Biochemistry 1998-04-03

...top1 deletions rendered cells hypersensitive to the drug. These results strongly suggest that DMP-840 acts against eukar...

Wu(J),Liu(L F) Nucleic Acids Res 1998-01-09

...TOP1 and T7 RNA polymerase. CPT-stabilized TOP1 cleavable complexes located on the template strand within the transcribe...

Van Dross(R T),Rao(K V),Eisenberg(E),Sande... Gene 1998-01-26

The topoisomerase I (TOP1) gene was cloned and sequenced from Aspergillus nidulans using the polymerase chain reaction (...

Hann(C),Evans(D L),Fertala(J),Benedetti(P)... J Biol Chem 1998-05-07

...Top1p yet did not appreciably increase the cytotoxic response of cells expressing a catalytically inactive (eSctop1Y727F...