Bian(Z),Gao(H),Wu(H),Yang(T) Biomolecules 2026-06-22

...TOP1), which modulated the SA-mediated immune response. Co-expression of AtHSPR and TOP1 showed that the TOP1 protein, n...

Prommachote(W),Deeudom(M),Manimaran(H),Kho... Int J Mol Sci 2026-06-28

...TOP1) and (4-(2-oxochromen-3-yl)benzoic acid (TOP2) exhibiting the most favorable binding energies at -12.0 and -11.8 kc...

Devos(P),Maroteau(G),Dartus(J) Orthop Traumatol Surg Res 2026-07-16

...Top1%, and 280 within the global Top10%. Moderate agreement was observed between the different selection models (Ka = 0....

Qian(M),Li(L),Cheng(Y),Hou(Y),Fu(S),Xu(Z) iScience 2026-06-19

...top1-out" sensitivity analysis. The models highlighted the predictive value of C3 and URBC by capturing non-linear patte...

Li(Y),Wu(Z),Chen(J),Ruan(Q),Yao(L),Shao(L)... Synth Syst Biotechnol 2026-12-00

...TOP1). Although the post-modifications of camptothecin (e.g., hydroxylation and subsequent methoxylation) have been well...

Kaur(H),Sood(V),Choubey(P),Sawant(M),Gogat... Cell Rep 2026-07-28

...TOP1 preferentially localizes to super-enhancers, and TLR activation results in the rapid redistribution of TOP1 from re...

Shan(C),Chen(Q),Sun(X),Hu(S),Bathini(T),Ya... J Am Chem Soc 2026-07-15

Aromatic camptothecins (CPTs) are clinically potent TOP1 inhibitors constrained by an "aromaticity-solubility" paradox, ...

Basu(S),Bhattacharyya(A),Khan(MA),Pal(U),C... Nucleic Acids Res 2026-05-20

...Top1 mutants (Top1KK) display impaired subnuclear mobility and accumulate elevated levels of trapped Top1-DNA covalent c...

Necchi(A),de Jong(JJ),Maiorano(BA),Proudfo... J Clin Oncol 2026-07-20

...TOP1-expressing tumors. Neoadjuvant SG, at the reduced dose of 7.5 mg/kg, was active with a manageable safety profile, c...

Roy(A),Ghosh(A),Bhoumick(A),Paul(S),Halder... Cancer Lett 2026-09-01

...Top1) as a critical downstream effector of thrombin-PAR1 driven inflammatory reprogramming in breast cancer cells. Throm...