Bras-Gonçalves(R A),Rosty(C),Laurent-Puig(... Br J Cancer 2000-04-05

Biological parameters influencing the response of human colorectal cancers (CRCs) to CPT-11, a topoisomerase 1 (top1) in...

Bennett(R J),Noirot-Gros(M F),Wang(J C) J Biol Chem 2000-10-03

...top1 double mutant lacking both Sgs1 and DNA topoisomerase I showed that the slow growth phenotype of this double mutant...

Pourquier(P),Takebayashi(Y),Urasaki(Y),Gio... Proc Natl Acad Sci U S A 2000-03-23

...top1), we found a 4- to 6-fold enhancement of top1 cleavage complexes when ara-C was incorporated at the +1 position (im...

Gupta(M),Fan(S),Zhan(Q),Kohn(K W),O'Connor... Clin Cancer Res 1999-03-22

Camptothecin (CPT) derivatives are topoisomerase I (top1) inhibitors recently introduced as clinical agents. To explore ...

Borovitskaya(A E),D'Arpa(P) Oncol Res 1999-01-04

...TOP1, EC 5.99.1.2) cause the reversible stabilization of the TOP1-DNA covalent complex (cleavable complex). The cleavabl...

Park(H),Sternglanz(R) Yeast 1999-06-29

...TOP1 and HPR1. The implications of these interactions for TOF2 function are discussed.

Beretta(G L),Binaschi(M),Zagni(E),Capuani(... Cancer Res 1999-09-07

...Top1 to establish whether the fusion protein had altered site specificity. Under conditions of reduced binding of Top1 t...

Takebayashi(Y),Pourquier(P),Yoshida(A),Koh... Proc Natl Acad Sci U S A 1999-07-19

...top1). Purified top1 was then tested and found to produce cleavage complexes in the presence of Et743, whereas topoisome...

Gallagher(D S),Schläpfer(J),Burzlaff(J D),... Chromosome Res 1999-07-21

...TOP1) previously assigned to human chromosomes 10 or 20 (HSA10 or HSA20). Four of the genes were found represented in th...

Duann(P),Sun(M),Lin(C T),Zhang(H),Liu(L F) Nucleic Acids Res 1999-09-03

...TOP1) poison which induces TOP1-mediated DNA damage. Within minutes, a large increase in the linking number (over 10 lin...