Edwards(T K),Saleem(A),Shaman(J A),Dennis(... J Biol Chem 2000-12-29

...Top1). We have now mapped the topoisomerase I interaction domain of nucleolin to the N-terminal 225 amino acids. We also...

Cushman(M),Jayaraman(M),Vroman(J A),Fukuna... J Med Chem 2000-11-08

In an attempt to design and synthesize potential anticancer agents acting by inhibition of topoisomerase I (top1), a new...

Bom(D),Curran(D P),Kruszewski(S),Zimmer(S ... J Med Chem 2000-11-16

...top1 cleavage complexes than camptothecin or SN-38. The impressive blood stability and cytotoxicity profiles for 14 stro...

Bennett(R J),Noirot-Gros(M F),Wang(J C) J Biol Chem 2000-10-03

...top1 double mutant lacking both Sgs1 and DNA topoisomerase I showed that the slow growth phenotype of this double mutant...

Zhang(C X),Chen(A D),Gettel(N J),Hsieh(T S... Dev Biol 2000-07-26

...top1-deficient flies with heat-shock-inducible top1 transgenes and were able to observe both zygotic and maternal functi...

Yanase(K),Sugimoto(Y),Tsukahara(S),Oh-Hara... Jpn J Cancer Res 2000-07-18

...TOP1 mRNA in HT-29 / CPT. The longer mRNA (4.0 kb) is the wild-type TOP1 mRNA, and the shorter mRNA (3.3 kb) proved to h...

Pommier(Y),Laco(G S),Kohlhagen(G),Sayer(J ... Proc Natl Acad Sci U S A 2000-11-03

DNA topoisomerase I (top1) is the target of potent anticancer agents, including camptothecins and DNA intercalators, whi...

Pourquier(P),Takebayashi(Y),Urasaki(Y),Gio... Proc Natl Acad Sci U S A 2000-03-23

...top1), we found a 4- to 6-fold enhancement of top1 cleavage complexes when ara-C was incorporated at the +1 position (im...

Pommier(Y),Kohlhagen(G),Pourquier(P),Sayer... Proc Natl Acad Sci U S A 2000-04-11

...top1 cleavage activity at the alkylation site and induce the formation of new top1cleavage complexes on both strands of ...

Bras-Gonçalves(R A),Rosty(C),Laurent-Puig(... Br J Cancer 2000-04-05

Biological parameters influencing the response of human colorectal cancers (CRCs) to CPT-11, a topoisomerase 1 (top1) in...