Balestrazzi(A),Bernacchia(G),Pitto(L),Lucc... Eur J Histochem 2001-11-01

...top1alpha and top1beta, both transcripts preferentially accumulated in tissues having mitotic activity.

Nitiss(J L),Nitiss(K C),Rose(A),Waltman(J ... J Biol Chem 2001-08-16

...TOP1) conferred hypersensitivity to methyl methanesulfonate and other DNA-damaging agents, whereas expression of a catal...

Smith(S F),Metcalfe(J A),Elgar(G) Gene 2001-05-03

...top1 genes in the pufferfish, Fugu rubripes. This shows that the copy number of top1, like that of other topoisomerases,...

Fan(Y),Shi(L M),Kohn(K W),Pommier(Y),Weins... J Med Chem 2001-10-25

Topoisomerase 1 (top1) inhibitors are proving useful against a range of refractory tumors, and there is considerable int...

Kerrigan(J E),Pilch(D S) Biochemistry 2001-12-07

...TOP1)-DNA cleavable complex, we have developed a general model for the ternary drug-DNA-TOP1 cleavable complex formed wi...

Zhang(H),Barceló(J M),Lee(B),Kohlhagen(G),... Proc Natl Acad Sci U S A 2001-11-01

...top1mt. The pattern of top1mt expression matches the requirement for high mitochondrial activity in specific tissues. to...

Chatterjee(D),Schmitz(I),Krueger(A),Yeung(... Cancer Res 2001-10-18

...Top1), an event followed by apoptosis of cancer cells. We investigated whether other mechanisms downstream of the DNA-To...

Vance(J R),Wilson(T E) Mol Cell Biol 2001-12-04

...Top1-DNA covalent complexes. Finally, the tpp1 apn1 apn2 triple mutation displayed synthetic lethality in combination wi...

Desai(S D),Li(T K),Rodriguez-Bauman(A),Rub... Cancer Res 2001-08-16

...TOP1 cleavable complexes, SUMO-1-TOP1 conjugates, and ubiquitin-TOP1 conjugates in ZR-75-1 and BT474 cells has suggested...

Cushman(M),Jayaraman(M),Vroman(J A),Fukuna... J Med Chem 2000-11-08

In an attempt to design and synthesize potential anticancer agents acting by inhibition of topoisomerase I (top1), a new...