Woo(Michael H),Losasso(Carmen),Guo(Hong),P... Proc Natl Acad Sci U S A 2004-02-02

...Top1-DNA complex necessitates some DNA distortion to allow rotation. To investigate the effects of Top1-clamp closure on...

Fagundes(Marcia R Z Kress),Fernandes(Laris... Genetics 2004-03-17

...TOP1) genes in the presence of DNA-damaging agents was observed. Overexpression of topoisomerase I in the scaA1 mutant c...

Ruchelman(Alexander L),Singh(Sudhir K),Ray... Bioorg Med Chem 2004-09-10

...TOP1-targeting activity was observed when the 11-position was substituted with either a 2-(N,N-dimethylamino)ethyl, a 2-...

Zhang(Hua-Feng),Tomida(Akihiro),Koshimizu(... Cancer Res 2004-04-09

...TOP1)-DNA covalent complexes are the initial lesions produced by antitumor camptothecins (CPTs). The TOP1-directed drugs...

Meng(L H),He(X X),Zhang(J S),Ding(J) Acta Pharmacol Sin 2004-01-12

...TOP1 deleted (JN394top1-) yeast cells were at the same level, suggesting Topo I might not be the cellular target of salv...

Pourquier(Philippe),Gioffre(Christopher),K... Clin Cancer Res 2003-02-26

...top1) activity and tested the role of top1 poisoning in gemcitabine-induced cytotoxicity in cancer cells.,We found that ...

Xu(Lixin),Yang(Lihong),Hashimoto(Keiko),An... BMC Genomics 2003-10-31

...TOP1 to the same cellular compartment, either the nucleus or the cytoplasm, co-localization was demonstrated in co-trans...

Liu(Chunyan),Pouliot(Jeffrey J),Nash(Howar... Proc Natl Acad Sci U S A 2003-01-15

...Top1 damage. In contrast, assays of growth in the presence of the Top1 poison camptothecin (CPT) indicate that the struc...

Ruchelman(Alexander L),Singh(Sudhir K),Wu(... Bioorg Med Chem Lett 2003-11-12

...TOP1 and DNA. Two analogues with very potent TOP1-targeting activity, 3a and 4a, exhibited cytotoxic activity with IC(50...

Singh(Sudhir K),Ruchelman(Alexander L),Li(... J Med Chem 2003-06-23

...TOP1-targeting activity and cytotoxicity. In the case of both the 8- and 9-nitro analogues, their TOP1-targeting activit...