Adachi(Noritaka),So(Sairei),Koyama(Hideki) J Biol Chem 2004-12-10

...Top1 by trapping cleavage complexes, thereby inducing Top1-linked single-strand breaks. Such DNA lesions are converted i...

Millgate(Anthony G),Pogson(Barry J),Wilson... Nature 2004-10-05

...top1 (for 'thebaine oripavine poppy 1'), which accumulates the morphine and codeine precursors thebaine and oripavine an...

Pommier(Yves) Curr Med Chem Anticancer Ag... 2004-11-08

...Top1) by trapping the catalytic intermediate of the Top1-DNA reaction, the cleavage complex. Hence, camptothecins repres...

Daroui(Parima),Desai(Shyamal D),Li(Tsai-Ku... J Biol Chem 2004-06-01

...TOP1) into covalent cleavage complexes. In this study, we have investigated the role of TOP1 in hydrogen peroxide toxici...

Plo(Isabelle),Liao(Zhi Yong),Barceló(Juana... DNA Repair (Amst) 2004-06-04

DNA topoisomerase I (Top1) is converted into a cellular poison by camptothecin (CPT) and various endogenous and exogenou...

Pommier(Yves),Redon(Christophe),Rao(V Ashu... Mutat Res 2004-01-20

...Top1 cleavage complexes. Top1 cleavage complexes damage DNA and kill cells by generating replication-mediated DNA double...

Facompré(Michaël),Tardy(Christelle),Bal-Ma... Cancer Res 2004-01-16

...top1 gene, were cross-resistant to LAM-D. Collectively, the results identify LAM-D as a novel lead candidate for the dev...

Antony(Smitha),Jayaraman(Muthusamy),Laco(G... Cancer Res 2004-01-16

...top1 and demonstrates that MJ-III-65 is a potentially useful top1 inhibitor that enhances and traps top1 cleavage sites ...

Li(Tsai-Kun),Houghton(Peter J),Desai(Shyam... Cancer Res 2004-02-27

...TOP1, suggesting that the cytotoxic target of ARC-111 is TOP1. Indeed, ARC-111, like CPT, was shown to induce reversible...

Streltsov(Sergei),Oleinikov(Vladimir),Ermi... Biopolymers 2004-01-09

...top1 loading position. The data presume the hypothesis of TPT-mediated modulation of top1-DNA recognition before ternary...