Liu(J),Li(M),Huang(J),Xia(Y),Jiang(G),Zhan... Cell Rep Med 2026-05-19

...TOP1-mediated DNA damage and cytotoxicity. We further discover that it concurrently suppresses the PERK-eIF2α-ATF4 axis ...

Pommier(Y) J Mol Biol 2026-08-15

...TOP1 poisons: Topotecan, Irinotecan and Belotecan. We review the determinants of response to tumor-targeted TOP1 poison ...

Umemura(K),Ooka(M),Sojo(M),Seki(M),Xia(M),... J Biol Chem 2026-04-00

...TOP1 and TOP2 resolve topological stress associated with DNA unwinding. Based on their catalytic activities, TOP1 is bel...

Hsu(CY),Baig(MR),Patel(PN),Singh(G),Abdelr... Crit Rev Oncol Hematol 2026-03-00

...TOP1 activity ratio, and EGFRvIII-associated replication stress, providing a framework for patient stratification and re...

Wang(W),Li(D),Liu(J),Li(L),Zhang(Q),Zhang(... J Med Chem 2026-08-13

...TOP1/PARP1 inhibitors that simultaneously induce SSBs via TOP1 inhibition and block their repair via PARP1 inhibition, c...

Wang(S),Xiang(Z),Wang(K),Nian(X),Song(Y),W... Water Res 2026-08-15

...Top1 branch localization reached 100%. Sensitivity analyses further showed that larger inflow magnitudes and hydraulical...

Martínez-Esquivias(F),Pech-Santiago(EO),Gu... Curr Comput Aided Drug Des 2026-05-13

...TOP1 is associated with B-cell and macrophage infiltration. Finally, molecular docking and molecular dynamics confirm st...

Liao(L),Tang(Z),Luo(P),Tang(R),Li(H),He(G)... Toxicol Appl Pharmacol 2026-10-00

...TOP1 and CDK2 mRNA, decreased the Bcl-2/Bax ratio, and increased cleaved caspase-3 levels. Quantitative validation by Ed...

Zeng(H),Zheng(X),Liu(J),Zhang(S),Nie(H),Wa... Mol Divers 2026-09-03

...TOP1) is a crucial anticancer target, but the development of traditional TOP1 inhibitors suffers from long research cycl...

Zhong(Z),Yokoyama(M),Kobayashi(T) Cell Rep 2026-07-28

...Top1. These abnormalities are partially dependent on canonical amplification recombination pathways, including those reg...