Uemura(T),Tanagida(M) EMBO J 2005-06-16

...top1-top2 described in the present paper can be explained by a previously proposed hypothesis that type II topoisomerase...

Morrell(Andrew),Antony(Smitha),Kohlhagen(G... Bioorg Med Chem Lett 2005-02-07

...top1) inhibition. The results indicate that these substances are a potent class of top1 inhibitors with sub-micromolar c...

Alessandri(Marco),Beretta(Giovanni L),Ferr... J Mol Biol 2004-04-23

...Top1 chimeric proteins (GalTop) with an N-terminal truncation of Top1, and mutations of the Gal4 Zn-cluster and/or Top1 ...

Antony(Smitha),Arimondo(Paola B),Sun(Jian-... Nucleic Acids Res 2004-10-13

...Top1-mediated DNA cleavage by affecting either or both the nicking and the closing activities of Top1 depending on the p...

Liu(Chunyan),Pouliot(Jeffrey J),Nash(Howar... DNA Repair (Amst) 2004-12-16

...Top1), decreased survival of camptothecin-induced damage. The relationship between the role of TDP1 in Saccharomyces and...

Chen(Allan Y),Chou(Rachel),Shih(Shyh-Jen),... Crit Rev Oncol Hematol 2004-12-17

...TOP1)-targeted drugs such as camptothecin derivatives represent a novel class of chemotherapeutic agents that have recen...

Antony(Smitha),Theruvathu(Jacob A),Brooks(... Nucleic Acids Res 2004-11-09

...Top1 nicking and closing activities. Using purified recombinant Top1, we show that Top1 nicking-closing activity remains...

Potenza(Leonardo),Sinigaglia(Barbara),Lupp... Cancer Genet Cytogenet 2004-04-14

...TOP1 chimera and also, for the first time, its reciprocal TOP1/NUP98. The literature review disclosed that, among six ca...

Chen(Allan Y),Shih(Shyh-Jen),Hsiao(Michael... Mol Pharmacol 2004-11-03

DNA topoisomerase I (TOP1) mediates the induction of radiosensitization (RS) by camptothecin derivatives in mammalian ce...

Materna(Verena),Pleger(Juliane),Hoffmann(U... Gynecol Oncol 2004-08-17

...TOP1) are associated with drug-resistant phenotypes in various model systems.,In ovarian specimens of 61 patients, the m...