Ruchelman(Alexander L),Houghton(Peter J),Z... J Med Chem 2005-03-07

...TOP1-targeting activity and pronounced antitumor activity. Several analogues of ARC-111 were synthesized with NH2, N-alk...

Chen(Allan Y),Shih(Shyh-Jen),Garriques(Liz... Mol Cancer Ther 2005-07-28

...TOP1)-mediated DNA-damaging activity, improved blood stability, and holds significant promise for the treatment of human...

Postma(C),Hermsen(M A J A),Coffa(J),Baak(J... J Pathol 2005-04-21

...TOP1, BCL2L1, and E2F1 had median copy number ratios of 2 or higher, while ZNF217 had a ratio around 3. In conclusion, f...

Strefford(Jon C),Stasevich(Irina),Lane(Tim... Cancer Genet Cytogenet 2005-06-09

...TOP1. An excellent correlation was observed between the genomic array and FISH data, demonstrating that this technique i...

Antony(Smitha),Kohlhagen(Glenda),Agama(Kel... Mol Pharmacol 2005-03-07

...Top1) reversibly like CPT but with different DNA sequence preferences. Consistent with Top1 poisoning, protein-linked DN...

Ruchelman(Alexander L),Zhu(Shejin),Zhou(Na... Bioorg Med Chem Lett 2005-03-22

The exceptional TOP1-targeting activity and antitumor activity of ARC-111, 1, prompted studies on similarly substituted ...

van Waardenburg(Robert C A M),de Jong(Laur... J Biol Chem 2005-03-14

...Top1 in vitro and demonstrate that persistent Pt-DNA adducts correlate with increased covalent Top1-DNA complexes in viv...

Kobzev(Yuri N),Martinez-Climent(Jose),Lee(... Genes Chromosomes Cancer 2005-08-19

...TOP1. In the 3 cases for which RNA was available, RT-PCR was performed, which confirmed the FISH results and identified ...

Sordet(Olivier),Khan(Qasim A),Plo(Isabelle... J Biol Chem 2005-02-07

...Top1 cleavage complexes. These complexes are formed indirectly as staurosporine cannot induce Top1 cleavage complexes in...

Laco(Gary S),Du(Wu),Kohlhagen(Glenda),Saye... Bioorg Med Chem 2005-04-18

...Top1 inhibitors through engineered interactions with as yet unutilized Top1 active-site residues including: Glu356, Asn4...