El-Khamisy(Sherif F),Saifi(Gulam M),Weinfeld… Nature 2005-03-09

...top1) peptide from DNA termini during the repair of double-strand breaks created by collision of replication forks with ...

Peñuelas(Silvia),Noé(Véronique),Ciudad(Carlo… FEBS J 2005-03-24

...TOP1) and vimentin as down-regulated genes. Changes in mRNA levels were validated by quantitative RT-PCR. Additionally, ...

Jacquiau(Hervé R),van Waardenburg(Robert C A… J Biol Chem 2005-09-29

...Top1p-induced DNA lesions, we described a yeast genetic screen for conditional tah (top1T722A-hypersensitive) mutants wi...

Vanhuyse(Marie),Kluza(Jérôme),Tardy(Christèl… Cancer Lett 2005-05-31

...top1 gene, display a functional Pgp, as judged from cytometry experiments performed with cells treated with rhodamine 12...

Staker(Bart L),Feese(Michael D),Cushman(Mark… J Med Chem 2005-05-05

Human topoisomerase I (top1) is the molecular target of a diverse set of anticancer compounds, including the camptotheci...

Xiao(Xiangshu),Antony(Smitha),Pommier(Yves),… J Med Chem 2005-06-03

...top1 inhibitors and as anticancer agents, and they will be important in the future design of indenoisoquinoline-based to...

Strefford(Jon C),Stasevich(Irina),Lane(Tim M… Cancer Genet Cytogenet 2005-06-09

...TOP1. An excellent correlation was observed between the genomic array and FISH data, demonstrating that this technique i...

Postma(C),Hermsen(M A J A),Coffa(J),Baak(J P… J Pathol 2005-04-21

...TOP1, BCL2L1, and E2F1 had median copy number ratios of 2 or higher, while ZNF217 had a ratio around 3. In conclusion, f...

Ruchelman(Alexander L),Houghton(Peter J),Zho… J Med Chem 2005-03-07

...TOP1-targeting activity and pronounced antitumor activity. Several analogues of ARC-111 were synthesized with NH2, N-alk...

Gurevich(Rhonna M),Aplan(Peter D),Humphries(… Blood 2005-02-09

...TOP1), a catalytic enzyme recognized for its key role in relaxing supercoiled DNA. We now show that retrovirally enginee...