Nagarajan(Muthukaman),Morrell(Andrew),Ioan... J Med Chem 2006-12-04

...Top1 inhibition. Molecular modeling of these compounds in complex with DNA and Top1 suggests that some of the lactam sub...

Ruchelman(Alexander L),Kerrigan(John E),Li... Bioorg Med Chem 2005-01-11

...TOP1-targeting agent with pronounced antitumor activity. In the present study, the effect on activity of substituting a ...

Ruchelman(Alexander L),Zhu(Shejin),Zhou(Na... Bioorg Med Chem Lett 2005-03-22

The exceptional TOP1-targeting activity and antitumor activity of ARC-111, 1, prompted studies on similarly substituted ...

van Waardenburg(Robert C A M),de Jong(Laur... J Biol Chem 2005-03-14

...Top1 in vitro and demonstrate that persistent Pt-DNA adducts correlate with increased covalent Top1-DNA complexes in viv...

Sordet(Olivier),Khan(Qasim A),Plo(Isabelle... J Biol Chem 2005-02-07

...Top1 cleavage complexes. These complexes are formed indirectly as staurosporine cannot induce Top1 cleavage complexes in...

Chen(Allan Y),Shih(Shyh-Jen),Garriques(Liz... Mol Cancer Ther 2005-07-28

...TOP1)-mediated DNA-damaging activity, improved blood stability, and holds significant promise for the treatment of human...

Glasgow(S C),Yu(J),Carvalho(L P),Shannon(W... Br J Cancer 2005-03-23

...TOP1). Mucinous tumours significantly overexpressed both TYMS and GSTP1 relative to nonmucinous tumours and patient-matc...

El-Khamisy(Sherif F),Saifi(Gulam M),Weinfe... Nature 2005-03-09

...top1) peptide from DNA termini during the repair of double-strand breaks created by collision of replication forks with ...

Peñuelas(Silvia),Noé(Véronique),Ciudad(Car... FEBS J 2005-03-24

...TOP1) and vimentin as down-regulated genes. Changes in mRNA levels were validated by quantitative RT-PCR. Additionally, ...

Jacquiau(Hervé R),van Waardenburg(Robert C... J Biol Chem 2005-09-29

...Top1p-induced DNA lesions, we described a yeast genetic screen for conditional tah (top1T722A-hypersensitive) mutants wi...