Moisan(F),Longy(M),Robert(J),Le Morvan(V) Br J Cancer 2006-11-14

...Top1), a nuclear enzyme involved in DNA relaxation, is the target of several anticancer drugs. TOP1 mutations occur in c...

Pommier(Yves) Nat Rev Cancer 2006-11-09

...TOP1 inhibitors are reviewed, and rational combinations of TOP1 inhibitors with other drugs are considered based on curr...

Kokkinakis(Demetrius M),Brickner(Anthony G... Mol Cancer Res 2006-10-12

...TOP1/POLB, MGMT/RAD52/RAD54, and cMET/RADD52, respectively. Sensitivity to these and additional genotoxic agents and rad...

Nagarajan(Muthukaman),Morrell(Andrew),Anto... J Med Chem 2006-10-03

...Top1) inhibitors that exert cytotoxicity by trapping the covalent complex formed between DNA and Top1 during relaxation ...

Morrell(Andrew),Jayaraman(Muthusamy),Nagar... Bioorg Med Chem Lett 2006-10-06

...Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top1 during cel...

Nitiss(Karin C),Malik(Mobeen),He(Xiaoping)... Proc Natl Acad Sci U S A 2006-09-11

...TOP1 is deleted. Finally, bacterially expressed yeast Tdp1p is able to remove a peptide derived from yTop2 that is coval...

Wilting(S M),Snijders(P J F),Meijer(G A),Y... J Pathol 2006-08-04

...TOP1. For DNMT3B, this correlated with elevated mRNA expression in 79% of cases. In conclusion, the assessment of freque...

Wu(Leonard),Bachrati(Csanad Z),Ou(Jiongwen... Proc Natl Acad Sci U S A 2006-04-25

...Top1 or Top3, both of which can also catalyze dissolution in a BLM-dependent manner. We present evidence that BLAP75/RMI...

Lebedeva(Natalia),Auffret Vander Kemp(Patr... DNA Repair (Amst) 2006-09-08

...Top1). To further establish the nature of crosslinked protein, yeast Top1 was tagged with a Myc-epitope. In this case, t...

Antony(Smitha),Agama(Keli K),Miao(Ze-Hong)... Mol Pharmacol 2006-09-28

...Top1 cleavage complexes at specific sites in biochemical assays. At higher concentrations, inhibition of Top1 catalytic ...