Liu(Jun-qing),Zhang(Wei-fang),Jin(Jie),Qia... Zhejiang Da Xue Xue Bao Yi ... 2006-11-30

...Top1 protein expression.,TPT can inhibit Mutz-1 cell growth and induce apoptosis in vitro.The downregulation of Top1 may...

Liao(Zhiyong),Thibaut(Laurent),Jobson(Andr... Mol Pharmacol 2006-10-24

...Top1) is the target of camptothecin, and novel Top1 inhibitors are in development as anticancer agents. Top1 inhibitors ...

Cline(Susan D),Hanawalt(Philip C) DNA Repair (Amst) 2006-07-31

...Top1, Top2, and Top3) in the yeast Saccharomyces cerevisiae were examined for their influence upon the nucleotide excisi...

Zhang(W),Shannon(W D),Duncan(J),Scheffer(G... J Pathol 2006-08-04

...TOP1), metabolism enzymes (CES2, UGT1A1, CYP3A4, CYP3A5), and cellular transporters of the anti-cancer agent (ABCB1, ABC...

Pond(Christopher D),Marshall(Kathryn M),Ba... Mol Cancer Ther 2006-05-26

...top1-directed drug action. Several peptides that bind top1 were discovered and these were examined for top1 affinity, to...

Romana(S P),Radford-Weiss(I),Ben Abdelali(... Leukemia 2006-09-08

...TOP1 genes were equally rearranged in de novo and in therapy-related myeloid proliferations. Involvement of ADD3 and C6O...

Davies(Douglas R),Mushtaq(Adeel),Interthal... J Mol Biol 2006-05-02

...TOP1S. Here, we present the 2.27A crystal structure of an active truncated L.donovani TOP1L/TOP1S heterodimer bound to n...

Adams(David J),da Silva(Mateus Webba),Flow... Cancer Chemother Pharmacol 2006-01-17

...top1 in addition to known contacts found for other camptothecins. More important, residues 350-356 and 425-431 of Core S...

Nebral(Karin),König(Margit),Schmidt(Helmut... Haematologica 2006-08-10

...TOP1 fusion, and one case with a putative new fusion partner gene at 3p24 was identified.,The observed frequency of 1.7%...

Gurevich(Rhonna M),Rosten(Patty M),Schwieg... Exp Hematol 2006-10-31

...TOP1 in leukemogenesis, we expressed NUP98-TOP1 in ICSBP(-/-) bone marrow.,The in vivo myeloproliferation induced by NUP...