Miao(Ze-Hong),Agama(Keli),Sordet(Olivier),... DNA Repair (Amst) 2007-02-28

...Top1) inhibitor camptothecin, we find enhanced levels of Top1 cleavage complexes (Top1cc) and defective reversal of Top1...

Khan(Qasim A),Pilch(Daniel S) J Mol Biol 2007-02-21

...TOP1)-mediated DNA cleavage (a behavior termed topoisomerase I poisoning) by interacting with both the DNA and the enzym...

Montaudon(Danièle),Palle(Komaraiah),Rivory... J Biol Chem 2007-06-28

...Top1 catalytic activity. We demonstrate that in contrast to CPT, which inhibits Top1-catalyzed religation, thiolation of...

Fietta(Am),Bardoni(Am),Salvini(R),Passador... Arthritis Res Ther 2007-02-23

...TOP1). Mass analysis did not determine one protein-spot. The two study groups revealed a significant difference in BALF ...

Benedetti(P),Benchokroun(Y),Houghton(P J),... Drug Resist Updat 2007-06-28

...top1 mutants in yeast strains deleted for TOP1 (top1Delta) have defined amino acid residues critical for enzyme function...

Khobta(Andriy),Ferri(Francesca),Lotito(Luc... J Mol Biol 2006-04-18

...Top1 was found to be enriched in active chromatin, therefore suggesting that Top1 inhibition at the transcribed template...

Nitiss(Karin C),Malik(Mobeen),He(Xiaoping)... Proc Natl Acad Sci U S A 2006-09-11

...TOP1 is deleted. Finally, bacterially expressed yeast Tdp1p is able to remove a peptide derived from yTop2 that is coval...

Antony(Smitha),Agama(Keli K),Miao(Ze-Hong)... Mol Pharmacol 2006-09-28

...Top1 cleavage complexes at specific sites in biochemical assays. At higher concentrations, inhibition of Top1 catalytic ...

Lebedeva(Natalia),Auffret Vander Kemp(Patr... DNA Repair (Amst) 2006-09-08

...Top1). To further establish the nature of crosslinked protein, yeast Top1 was tagged with a Myc-epitope. In this case, t...

Morrell(Andrew),Jayaraman(Muthusamy),Nagar... Bioorg Med Chem Lett 2006-10-06

...Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top1 during cel...