El-Khamisy(Sherif F),Hartsuiker(Edgar),Cal... DNA Repair (Amst) 2007-12-19

...Top1)-DNA intermediates. Here we demonstrate that TDP1 is also required for the repair of SSBs induced by ionizing radia...

Hu(Hong-gang),Scholten(Ingo),Gruss(Claudia... Biochem Biophys Res Commun 2007-08-09

...TOP1 gene was highly enriched in the chromatin immunoprecipitates. This enrichment was lost when cells were treated with...

Katyal(Sachin),el-Khamisy(Sherif F),Russel... EMBO J 2007-12-17

...Top1-DNA complexes or oxidative damage. Moreover, loss of Tdp1 resulted in age-dependent and progressive cerebellar atro...

Song(Juan),Hu(Joyce),Tanouye(Mark) J Neurosci 2007-04-05

...top1(JS) suppression, providing additional support for a neural apoptosis suppression mechanism. The top1(JS) mutation i...

Montaudon(Danièle),Palle(Komaraiah),Rivory... J Biol Chem 2007-06-28

...Top1 catalytic activity. We demonstrate that in contrast to CPT, which inhibits Top1-catalyzed religation, thiolation of...

Benedetti(P),Benchokroun(Y),Houghton(P J),... Drug Resist Updat 2007-06-28

...top1 mutants in yeast strains deleted for TOP1 (top1Delta) have defined amino acid residues critical for enzyme function...

Lauria(Antonino),Ippolito(Mario),Almerico(... J Mol Model 2007-04-02

Topoisomerase I (Top1) is an essential enzyme participating to all those processes associated with separation of DNA str...

Cioci(Francesco),Di Felice(Francesca),Chia... Ital J Biochem 2007-09-14

...top1 strain, because rDNA specific transcriptional silencing is abolished. Nonetheless, the molecular basis of how this ...

He(Xiaoping),van Waardenburg(Robert C A M)... J Mol Biol 2007-12-11

...Top1) poison camptothecin. A more severe Top1-dependent lethality of Tdp1H(432)N was drug-independent, coinciding with i...

Vasconcellos(Marne C),Rosa(Renato M),Macha... Mutat Res 2007-08-10

...Top1 directly affects chromatin remodeling, allowing repair factors to access oxidative damage, which explains the high ...