Lin(Chao-Po),Ban(Yi),Lyu(Yi Lisa),Desai(Sh... J Biol Chem 2008-09-08

...Top1, a phenomenon termed Top1 down-regulation. In the current study, we have investigated the role of Top1 down-regulat...

Dexheimer(Thomas S),Antony(Smitha),Marchan... Anticancer Agents Med Chem 2008-06-23

...Top1). For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes, which can be...

Sordet(Olivier),Larochelle(Stéphane),Nicol... J Mol Biol 2008-11-03

...Top1)-DNA cleavage complexes. In addition to DNA modifications (base damages and strand breaks), Top1 cleavage complexes...

Burgess(Darren J),Doles(Jason),Zender(Lars... Proc Natl Acad Sci U S A 2008-07-31

...Top1 produces resistance to the topoisomerase 1 poison camptothecin yet hypersensitizes cancer cells to doxorubicin. Imp...

Sordet(Olivier),Goldman(Abby),Redon(Christ... J Biol Chem 2008-10-06

...Top1cc. We also show that TRAIL-induced apoptotic Top1cc are preferentially formed by caspase-3-cleaved Top1 at sites of...

Miao(Ze-Hong),Player(Audrey),Shankavaram(U... Cancer Res 2007-11-27

...Top1) have been difficult to study because knocking out TOP1 is lethal in metazoans. To reveal the functions of human To...

El-Khamisy(Sherif F),Hartsuiker(Edgar),Cal... DNA Repair (Amst) 2007-12-19

...Top1)-DNA intermediates. Here we demonstrate that TDP1 is also required for the repair of SSBs induced by ionizing radia...

Hu(Hong-gang),Scholten(Ingo),Gruss(Claudia... Biochem Biophys Res Commun 2007-08-09

...TOP1 gene was highly enriched in the chromatin immunoprecipitates. This enrichment was lost when cells were treated with...

Bermejo(Rodrigo),Doksani(Ylli),Capra(Thelm... Genes Dev 2007-09-26

...top1 top2 mutants. Our data are consistent with a coordinated action of Top1 and Top2 in counteracting the accumulation ...

He(Xiaoping),van Waardenburg(Robert C A M)... J Mol Biol 2007-12-11

...Top1) poison camptothecin. A more severe Top1-dependent lethality of Tdp1H(432)N was drug-independent, coinciding with i...