Zhang(Hongliang),Pommier(Yves) Biochemistry 2008-11-14

...Top1). In this study, we provide biochemical evidence of the presence of an endogenous Top1mt polypeptide in human mitoc...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Bioorg Med Chem Lett 2008-08-25

Several new TOP1-targeting agents were prepared using as intermediates the N,N,N-trimethyl quaternary ammonium salts of ...

Burgess(Darren J),Doles(Jason),Zender(Lars... Proc Natl Acad Sci U S A 2008-07-31

...Top1 produces resistance to the topoisomerase 1 poison camptothecin yet hypersensitizes cancer cells to doxorubicin. Imp...

Desai(Shyamal D),Wood(Laurence M),Tsai(Yu-... Mol Cancer Ther 2008-08-22

...TOP1)-DNA covalent complexes. First, short hairpin RNA-mediated knockdown of either ISG15 or UbcH8 (major E2 for ISG15) ...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Bioorg Med Chem 2008-12-05

...TOP1-targeting activity and cytotoxicity were assessed. Comparative data indicate that TOP1-targeting was often the prim...

Brusa(Gianluca),Zuffa(Elisa),Hattinger(Cla... Oncol Rep 2008-01-23

...TOP1, involved in DNA recombination and repair; WT1, a transcription factor involved in CD8+ T cell response against leu...

Gounder(Murugesan K),Nazar(Ahamed S),Salee... Invest New Drugs 2008-07-28

...TOP1) mutations.

Hammer(Eva),Heilbronn(Regine),Weger(Stefan... FEBS Lett 2008-02-04

Human Topors has originally been identified as binding partner of p53 and DNA topoisomerase I (TOP1). It can function as...

Houseley(Jonathan),Kotovic(Kimberly),El Ha... EMBO J 2008-03-07

...Top1 caused dramatic loss of rDNA repeats. Chromatin immunoprecipitation analyses showed that Trf4 is co-transcriptional...

Lassmann(Silke),Weis(Roland),Makowiec(Fran... J Mol Med (Berl) 2008-01-24

...TOP1, AIB1, MYBL2, CAS, PTPN1, STK15, ZNF217, and CYP24), two genes on chromosome 13q (BRCA2 and D13S25), and three gene...