Jha(RK),Kouzine(F),Wang(B),Phelan(JD),Das(... bioRxiv 2026-01-19

...TOP1 either through genetic knockdown or low-dose inhibition potentiates transcription amplification by MYC. This enhanc...

Kornienko(TE),Chepanova(AA),Kolobenko(MV),... Curr Issues Mol Biol 2026-04-21

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. ...

Guha Majumdar(A),Chauhan(N),Gupta(P),Subra... EMBO J 2026-06-00

...TOP1 cleavage complexes or TOP1-DNA covalent complexes, i.e., TOP1ccs) become highly genotoxic when stabilized. While me...

Scaglione(S),Gaillard(PH) Nucleic Acids Res 2026-05-05

...TOP1, and PARP inhibition. Instead, DNA binding is required in response to ICL-inducing agents and MMS but not after TOP...

Mestareehi(A) Oncol Res None

...TOP1, TOP2A, TOP2B, and C1orf35 in HCC and to characterize their associated molecular features to identify potential dia...

Ryabykh(GK),Osintseva(ED),Ashniev(GA),Maku... Int J Mol Sci 2026-04-19

...TOP1) consistently upregulated in both HCT116 cells and patient tumors and positively correlated with SNHG1, with the co...

Zhang(Z),Zong(H),Li(Z),Wang(S),Xiao(X),Xie... Pharmaceuticals (Basel) 2026-04-08

...TOP1 inhibitor DXd. This design combined moderate affinity and acceptable pharmacokinetics, resulting in potent antitumo...

Sarrain(EJ),Wang(Q),Bondoy(AC),Guo(F),Cao(... bioRxiv 2026-04-21

...TOP1 cleavage complex (TOP1cc). In addition, TOP1cc formation can lead to 2- to 5-bp slippage deletions, recently identi...

Zeng(H),Qiu(B),Yang(J),Xie(Y),Huang(H),Zha... J Med Chem 2026-05-14

...TOP1) inhibitor, is widely used for advanced or recurrent disease; however, its efficacy is compromised by tyrosyl-DNA p...

Zhangding(Z),Liu(X),Liang(H),Fan(Y),Peng(Y... Mol Cell 2026-05-21

...TOP1). Conversely, head-on transcription potentially impairs fork elongation to weaken replication fountains. This study...