Takagi(Kazutaka),Dexheimer(Thomas S),Redon... Mol Cancer Ther 2008-03-19

...Top1 and selective against Top1 in yeast and human cancer cells. The keto analogues show improved cytotoxicity toward co...

Will(Joanna),Sheldrick(William S),Wolters(... J Biol Inorg Chem 2008-08-08

...top1). Two efflux proteins (acrD, mdtA), the redox regulator thioredoxin 1 (thiO) and the external filament-like type-1 ...

Sirikantaramas(Supaart),Yamazaki(Mami),Sai... Proc Natl Acad Sci U S A 2008-05-28

...Top1), the enzyme that catalyzes changes in DNA topology. We found that CPT-producing plants, including Camptotheca acum...

Lassmann(Silke),Weis(Roland),Makowiec(Fran... J Mol Med (Berl) 2008-01-24

...TOP1, AIB1, MYBL2, CAS, PTPN1, STK15, ZNF217, and CYP24), two genes on chromosome 13q (BRCA2 and D13S25), and three gene...

Saraiya(Biren),Gounder(Murugesan),Dutta(Ja... Anticancer Drugs 2008-07-28

Resistance to topoisomerase I (TOP1)-targeting drugs such as topotecan often involves upregulation of topoisomerase II (...

Satyanarayana(Mavurapu),Feng(Wei),Cheng(Li... Bioorg Med Chem 2008-10-29

...TOP1) targeting activity and antitumor activity. The influence of various polar substituents at the 2-position of the 11...

Palle(Komaraiah),Pattarello(Luca),van der ... J Biol Chem 2008-11-10

...Top1 clamp around duplex DNA would restrict DNA strand rotation within the covalent Top1-DNA intermediate. The active si...

Goswami(Anindya),Qiu(Shirley),Dexheimer(Th... Cancer Res 2008-09-08

...TOP1-DNA interface to form cleavage complexes, Par-4 interacts with TOP1 via its leucine zipper domain and sequesters TO...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Bioorg Med Chem 2008-12-05

...TOP1-targeting activity and cytotoxicity were assessed. Comparative data indicate that TOP1-targeting was often the prim...

Ramadan(Emad),Ward(Michael),Guo(Xin),Durki... Retrovirology 2008-12-02

...TOP1, Chk2, 53BP1). The first-neighbor and second-neighbor interactions of these four proteins were assembled from avail...