Cinelli(Maris A),Morrell(Andrew),Dexheimer... J Med Chem 2008-09-08

The aromathecin or "rosettacin" class of topoisomerase I (top1) inhibitors is effectively a "composite" of the natural p...

Sordet(Olivier),Goldman(Abby),Redon(Christ... J Biol Chem 2008-10-06

...Top1cc. We also show that TRAIL-induced apoptotic Top1cc are preferentially formed by caspase-3-cleaved Top1 at sites of...

Hoskins(Janelle M),Marcuello(Eugenio),Alte... Clin Cancer Res 2008-05-20

...TOP1), and downstream effectors may influence patient outcomes to irinotecan therapy. We undertook a retrospective candi...

Gao(Kai),Lockwood(William W),Li(Jun),Lam(W... Int J Oncol 2008-07-30

...TOP1, SPO11, TOP3B) as well as at the loci of genes guarding chromosomal stability (TP53, ZW10, H2AFX, CHK1, CCDN1, MCM5...

Palle(Komaraiah),Pattarello(Luca),van der ... J Biol Chem 2008-11-10

...Top1 clamp around duplex DNA would restrict DNA strand rotation within the covalent Top1-DNA intermediate. The active si...

Sordet(Olivier),Larochelle(Stéphane),Nicol... J Mol Biol 2008-11-03

...Top1)-DNA cleavage complexes. In addition to DNA modifications (base damages and strand breaks), Top1 cleavage complexes...

Sirikantaramas(Supaart),Yamazaki(Mami),Sai... Proc Natl Acad Sci U S A 2008-05-28

...Top1), the enzyme that catalyzes changes in DNA topology. We found that CPT-producing plants, including Camptotheca acum...

Song(Yunlong),Cushman(Mark) J Phys Chem B 2008-09-16

...top1 in its binding with the top1-DNA complex. This observation raises the possibility that hydrogen bonding between the...

Takagi(Kazutaka),Dexheimer(Thomas S),Redon... Mol Cancer Ther 2008-03-19

...Top1 and selective against Top1 in yeast and human cancer cells. The keto analogues show improved cytotoxicity toward co...

Verbiest(Vincent),Montaudon(Danièle),Tautu... FEBS Lett 2008-07-09

...Top1 inhibitor camptothecin (CPT). This effect was not due to a change in Top1 contents or catalytic activity, or to a d...