Malina(Jaroslav),Vrana(Oldrich),Brabec(Vik... Nucleic Acids Res 2009-11-17

...top1 activity. Interestingly, the effects of Pt-DNA adducts on the catalytic activity of top1 in the presence of camptot...

Sordet(Olivier),Redon(Christophe E),Guirou... EMBO Rep 2009-10-15

...TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent transcription-blocking lesions-also pro...

Lin(Chao-Po),Ban(Yi),Lyu(Yi Lisa),Liu(Lero... J Biol Chem 2009-11-10

Reversible topoisomerase I (Top1)-DNA cleavage complexes are the key DNA lesion induced by anticancer camptothecins (CPT...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Bioorg Med Chem 2009-06-12

...TOP1-targeting agents. Studies were performed to further evaluate the potential of this series of non-camptothecin TOP1-...

El-Khamisy(Sherif F),Katyal(Sachin),Patel(... DNA Repair (Amst) 2009-08-06

...Top1) peptide. Notably, the global rate of repair of oxidative and alkylation-induced SSBs was significantly slower in T...

Marchand(Christophe),Lea(Wendy A),Jadhav(A... Mol Cancer Ther 2009-02-19

...Top1)-DNA adducts accumulated from natural DNA damage as well as from the action of certain anticancer drugs. Tdp1 catal...

Ding(Li),Qiu(Lei),Zhang(Junping),Guo(Baoyu... Biol Pharm Bull 2009-07-24

...Top1), thereby activating many downstream signaling pathways. Although several pathways induced by CPT have been elucida...

Gorodetsky(Elena),Calkins(Sarah),Ahn(Julia... DNA Repair (Amst) 2008-02-26

...TOP1) in the nucleus, and specifically the nucleolus, of human Purkinje neurons. Our results have direct implications fo...

Houseley(Jonathan),Kotovic(Kimberly),El Ha... EMBO J 2008-03-07

...Top1 caused dramatic loss of rDNA repeats. Chromatin immunoprecipitation analyses showed that Trf4 is co-transcriptional...

Gounder(Murugesan K),Nazar(Ahamed S),Salee... Invest New Drugs 2008-07-28

...TOP1) mutations.