Qiu(Zhijun),Wang(Xicheng) Protein Pept Lett 2009-10-27

...Top1 and Top2) are used to detect ligand-binding pockets. The results show that the atom-contact-pair method has good ac...

Malina(Jaroslav),Vrana(Oldrich),Brabec(Vik... Nucleic Acids Res 2009-11-17

...top1 activity. Interestingly, the effects of Pt-DNA adducts on the catalytic activity of top1 in the presence of camptot...

Pfister(Thomas D),Reinhold(William C),Agam... Mol Cancer Ther 2009-10-19

...Top1, which we used to measure Top1 levels in the NCI-60 cancer cell line panel. Top1 levels ranged from 0.9 to 9.8 ng/m...

Hartsuiker(Edgar),Neale(Matthew J),Carr(An... Mol Cell 2009-02-04

...Top1 from 3' ends in vivo. A ctp1(CtIP) deletion is defective for Top2 removal but overproficient for Top1 removal, sugg...

de la Loza(M C Díaz),Wellinger(R E) Nucleic Acids Res 2009-04-06

...top1 Delta cells should lead to petite formation in the presence of camptothecin. Interestingly, camptothecin failed to ...

Marchand(Christophe),Lea(Wendy A),Jadhav(A... Mol Cancer Ther 2009-02-19

...Top1)-DNA adducts accumulated from natural DNA damage as well as from the action of certain anticancer drugs. Tdp1 catal...

Lotito(Luca),Russo(Alessandra),Bueno(Susan... Eur J Pharmacol 2009-03-18

...Top1) is the specific target of the anticancer drug camptothecin (CPT) that interferes with enzyme activity promoting To...

Diella(Francesca),Chabanis(Sophie),Luck(Ka... Bioinformatics 2009-01-28

...Top1; and the transcriptional regulatory kinases HIPK1 and HIPK2. The KEPEmotif appears to be restricted to the metazoan...

Dexheimer(Thomas S),Pommier(Yves) Nat Protoc 2009-01-22

...Top1 inhibitors still persists. Here, we describe one of the most frequently used protocols to identify novel Top1 inhib...

Sordet(Olivier),Redon(Christophe E),Guirou... EMBO Rep 2009-10-15

...TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)-which are potent transcription-blocking lesions-also pro...