Toyoda(Eriko),Kurosawa(Aya),Fujii(Michihik... Biol Pharm Bull 2009-05-12

...Top1 gene (TOP1) by gene targeting in a human pre-B cell line, Nalm-6, which is karyotypically stable and normal for p53...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Bioorg Med Chem 2009-06-12

...TOP1-targeting agents. Studies were performed to further evaluate the potential of this series of non-camptothecin TOP1-...

El-Khamisy(Sherif F),Katyal(Sachin),Patel(... DNA Repair (Amst) 2009-08-06

...Top1) peptide. Notably, the global rate of repair of oxidative and alkylation-induced SSBs was significantly slower in T...

Feng(Wei),Satyanarayana(Mavurapu),Tsai(Yua... Eur J Med Chem 2009-10-14

...TOP1-targeting agents. The relative TOP1-targeting activities and cytotoxicities were evaluated in RPMI8402 and P388 cel...

Spisák(Sándor),Galamb(Barnabás),Wichmann(B... Orv Hetil 2009-09-25

...TOP1, APC, CBP, ERK, EGFR, C-myc, Cald, DARPP32, MRE11A, AR, EPS8).,Based on these results, validated colorectal cancer ...

Siu(Fung-Ming),Che(Chi-Ming) J Am Chem Soc 2009-01-26

...top1-DNA covalent complexes. There is significant variation in the persistence of the resultant CPTs-top1-DNA ternary co...

Sharma(Lisa),Tsai(Yuan-Chin),Liu(Angela A)... Eur J Med Chem 2009-07-01

...TOP1-targeting activity or potent cytotoxic activity has not been explored. The present study examines the influence on ...

Dalla Rosa(Ilaria),Goffart(Steffi),Wurm(Me... Nucleic Acids Res 2009-12-21

...Top1 and Top1mt). To assess the meaning of this gene duplication, we targeted Top1 to mitochondria or Top1mt to nuclei. ...

Lin(Chao-Po),Ban(Yi),Lyu(Yi Lisa),Liu(Lero... J Biol Chem 2009-11-10

Reversible topoisomerase I (Top1)-DNA cleavage complexes are the key DNA lesion induced by anticancer camptothecins (CPT...

Qiu(Zhijun),Wang(Xicheng) Protein Pept Lett 2009-10-27

...Top1 and Top2) are used to detect ligand-binding pockets. The results show that the atom-contact-pair method has good ac...