Baranello(Laura),Bertozzi(Davide),Fogli(Ma... Nucleic Acids Res 2010-02-12

...Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing ...

Cinelli(Maris A),Cordero(Brenda),Dexheimer... Bioorg Med Chem 2010-01-19

The aromathecin topoisomerase I (top1) inhibitors offer promising scaffolds for the development of novel cancer chemothe...

Hoskins(Janelle M),Rosner(Gary L),Ratain(M... Pharmacogenomics 2010-03-25

A recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with ...

Wang(Ping),Ownby(Stacy),Zhang(Zhizhen),Yua... Bioorg Med Chem Lett 2010-07-27

...TOP1 catalytic activity by interacting directly with the free enzyme and preventing the formation of the DNA-TOP1 comple...

Das(Benu Brata),Dexheimer(Thomas S),Maddal... Proc Natl Acad Sci U S A 2010-12-21

...Top1)-DNA covalent complexes. TDP1 can also hydrolyze other 3'-end DNA alterations including 3'-phosphoglycolate and 3'-...

Wu(Ning),Wu(Xi-Wei),Agama(Keli),Pommier(Yv... Biochemistry 2010-12-30

DNA topoisomerase I (Top1) is an essential nuclear enzyme and a validated target for anticancer agent screening. In a pr...

Duro(Eris),Lundin(Cecilia),Ask(Katrine),Sa... Mol Cell 2010-12-30

...TOP1 inhibitor camptothecin are resected normally, but the loading of the RAD51 recombinase is defective. Therefore, MMS...

Spisák(Sándor),Galamb(Barnabás),Wichmann(B... Orv Hetil 2009-09-25

...TOP1, APC, CBP, ERK, EGFR, C-myc, Cald, DARPP32, MRE11A, AR, EPS8).,Based on these results, validated colorectal cancer ...

Qiu(Zhijun),Wang(Xicheng) Protein Pept Lett 2009-10-27

...Top1 and Top2) are used to detect ligand-binding pockets. The results show that the atom-contact-pair method has good ac...

Tuduri(Sandie),Crabbé(Laure),Conti(Chiara)... Nat Cell Biol 2009-11-16

...Top1. Taken together, these data indicate that Top1 prevents replication fork collapse by suppressing the formation of R...