Zander(Serge A L),Kersbergen(Ariena),van d... Cancer Res 2010-04-07

...Top1) poison topotecan as monotherapy and in combination with poly(ADP-ribose) polymerase inhibition by olaparib. All 20...

Han(Bingnan),Stockwin(Luke H),Hancock(Chad... J Proteome Res 2010-12-07

The indenoisoquinoline NSC724998 is a novel topoisomerase I (Top1) inhibitor entering Phase I clinical trials at the Nat...

Ye(Jing),Lenain(Christelle),Bauwens(Serge)... Cell 2010-08-16

...TOP1, TOP2alpha, and TOP2beta at telomeres. Our data are consistent with a model in which TRF2 and Apollo relieve topolo...

Umeda(Aiko),Thibodeaux(Gabrielle Nina),Mon... Anal Biochem 2010-11-04

...TOP1-DOPA-GFP). TOP1-DOPA-GFP produced from Escherichia coli was used in a Western blot-type experiment to show that the...

Beretta(G L),Cossa(G),Gatti(L),Zunino(F),P... Curr Med Chem 2010-07-28

...Top1) poison camptothecins are related to the generation of DNA lesions and tumor cells may be resistant to DNA damaging...

Huang(Ting-Hsiang),Chen(Hsiang-Chin),Chou(... Cell Res 2010-12-14

...TOP1cc), degradation of TOP1 and activation of DNA damage responses (DDR). Transcription and proteasome-dependent proteo...

Cinelli(Maris A),Morrell(Andrew E),Dexheim... Bioorg Med Chem 2010-11-02

Aromathecins are inhibitors of human topoisomerase I (Top1). These compounds are composites of several heteroaromatic sy...

El Hage(Aziz),French(Sarah L),Beyer(Ann L)... Genes Dev 2010-08-10

...Top1, and their frequency was exacerbated when RNase H activity was also lacking. We conclude that the loss of Top1 enha...

Pommier(Yves),Leo(Elisabetta),Zhang(HongLi... Chem Biol 2010-09-15

...Top1), whereas human type IIA topoisomerases (Top2alpha and Top2beta) are the targets of the widely used anticancer agen...

Wu(Ning),Wu(Xi-Wei),Agama(Keli),Pommier(Yv... Biochemistry 2010-12-30

DNA topoisomerase I (Top1) is an essential nuclear enzyme and a validated target for anticancer agent screening. In a pr...