Oussedik(Kahina),François(Jean-Christophe)... FASEB J 2010-08-03

We and others have clearly demonstrated that a topoisomerase I (Top1) inhibitor, such as camptothecin (CPT), coupled to ...

Park(Chung Mu),Youn(Hyun Joo),Chang(Hee Ky... Food Chem Toxicol 2010-07-06

...TOP1 and 2 (304, 92 mg/kg bw) were administered for 7 days via a stomach sonde, and hepatitis was induced by a single do...

Beretta(G L),Cossa(G),Gatti(L),Zunino(F),P... Curr Med Chem 2010-07-28

...Top1) poison camptothecins are related to the generation of DNA lesions and tumor cells may be resistant to DNA damaging...

Baldwin(Thomas K),Urban(Martin),Brown(Neil... Mol Plant Microbe Interact 2010-06-07

...top1 mutants of both species exhibited greatly reduced virulence in wheat ear infection assays (GO:0009405 and GO:004414...

Lebedeva(N A),Rechkunova(N I),Agama(K),Pom... Biochemistry (Mosc) 2010-02-02

...Top1) with linear and circular DNA structures containing a nick or short gap but lacking a specific Top1 recognition sit...

Alchanati(Iris),Teicher(Carmit),Cohen(Gali... PLoS One 2010-03-17

...Top1, Top2alpha and Top2beta are important molecular targets for antitumor drugs, which specifically poison Top1 or Top2...

El Hage(Aziz),French(Sarah L),Beyer(Ann L)... Genes Dev 2010-08-10

...Top1, and their frequency was exacerbated when RNase H activity was also lacking. We conclude that the loss of Top1 enha...

Cinelli(Maris A),Morrell(Andrew E),Dexheim... Bioorg Med Chem 2010-11-02

Aromathecins are inhibitors of human topoisomerase I (Top1). These compounds are composites of several heteroaromatic sy...

Reinhold(William C),Mergny(Jean-Louis),Liu... Cancer Res 2010-04-26

...TOP1 mRNA expression was highly correlated with Top1 protein levels, indicating that TOP1 transcripts could be convenien...

Huang(Ting-Hsiang),Chen(Hsiang-Chin),Chou(... Cell Res 2010-12-14

...TOP1cc), degradation of TOP1 and activation of DNA damage responses (DDR). Transcription and proteasome-dependent proteo...