Lippert(Malcolm J),Kim(Nayun),Cho(Jang-Eun... Proc Natl Acad Sci U S A 2011-02-24

...Top1-dependent deletions even in the absence of high transcription. We suggest that the accumulation of Top1 cleavage co...

Reid(Robert J D),González-Barrera(Sergio),... Genome Res 2011-06-24

...TOP1) into the haploid yeast gene-disruption library. Overexpression of Top1 identified only one sensitive mutation, rpa...

Ricci(Antonio),Marinello(Jessica),Bortolus... J Med Chem 2011-04-19

...Top1) able to form a ternary complex with the Top1-DNA complex. The aim of this investigation was to examine the dynamic...

Sasine(Joshua P),Savaraj(Niramol),Feun(Lyn... Anticancer Agents Med Chem 2011-06-01

...TOP1 inhibitors are currently being evaluated in phase I trials. TOP1 inhibitors show promising activity in patients wit...

Gmeiner(William H),Salsbury(Freddie),Olsen... J Nucleic Acids 2011-11-10

...Top1 cleavage site inhibits DNA religation. The reduced efficiency for Top1-mediated religation contributes to the antic...

Laco(Gary S) PLoS One 2011-12-23

...Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimate...

Kim(Nayun),Huang(Shar-yin N),Williams(Jess... Science 2011-07-06

...Top1, a topoisomerase that relaxes supercoils by reversibly nicking duplex DNA. The reported studies extend the role of ...

Ahowesso(Constance),Li(Xiao-Mei),Zampera(S... Chronobiol Int 2011-11-09

...Top1 were unchanged or down-regulated according to irinotecan timing and sex. This study shows that the circadian timing...

Kim(Nayun),Jinks-Robertson(Sue) DNA Repair (Amst) 2011-12-20

...Top1, possibly due to enhanced R-loop formation. Loss of Sgs1 helicase and RNase H activity also increased instability, ...

Sperling(Adam S),Jeong(Kyeong Soo),Kitada(... Proc Natl Acad Sci U S A 2011-10-27

...Top1 for optimal recruitment of RNA polymerase II at their promoters. These findings and the examination of candidate-ac...