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CRISPR/Cas9-mediated TOP1 knockout in chicken DF-1 cells reveals its critical...

Lv(X),Wei(Q),Zhi(Q),Liu(X),Li(F),Niu(Y),Su... J Anim Sci 2026-01-08

...TOP1 knockout platform in chicken DF-1 cells and evaluate its functional impact on apoptosis. Three sgRNAs targeting TOP...

Visualizing DNA repair factor recruitment at sites of transcription in single...

Guan(T),Shi(Y),Lee(TH),Oberdoerffer(P) Chromosome Res 2026-01-03

...TOP1 cleavage complex formation and concomitant DNA repair factor engagement. We expect this system to provide a powerfu...

Synthesis and biological evaluation of phenanthridine derivatives as dual-tar...

Gao(JM),Xie(H),Wang(ZQ),Huang(Y),Ouyang(Y)... Eur J Med Chem 2026-02-15

...TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) are key enzymes involved in DNA replication and repair, and their coord...

Topoisomerases regulate alternative transcription start site selection in yeast.

Elgood Hunt(E),Vivori(C),Albihlal(WS),van ... G3 (Bethesda) 2026-03-04

...Top1 and Top2) during early meiosis, where alternative TSS usage is prevalent, and applied an improved TSS sequencing pr...

LNP-Mediated CF10 Delivery Selectively Enhances Potency to Colorectal Cancer ...

Sarkar(S),Behl(A),Gmeiner(WH) ACS Appl Bio Mater 2026-02-16

...Top1). This study proposes the incorporation of CF10 into LNPs using chaotic mixing of lipid compositions in a microflui...

ASTWAS: modeling alternative polyadenylation and SNP effects in kernel-driven...

Wang(Y),Wang(L),Sheng(N),Hong(J),Liu(Y),Wu... Brief Bioinform 2026-01-07

...TOP1) to quantify SNP impacts on distal poly(A) site choice via the percentage of distal poly(A) site usage index, and t...

Network Pharmacology Reveals Luteolin From Vitex Negundo Novel Targets CDK1/C...

Basnet(R),Basnet(BB),Zhaojian(S),Amissah(O... Anticancer Agents Med Chem 2026-01-09

...TOP1, GSK-3β, and PARP1. Mutational analysis in MCF-7 cells followed by luteolin (LT) treatment assessed its impact on s...

[Evaluating the performance of generative AI in assisting the differential di...

Liu(Y),Zhang(Y),Cai(D),Ren(J) Zhejiang Da Xue Xue Bao Yi ... 2026-01-25

...Top1 diagnosis, but the differences among the three Qwen3 models across all diagnostic levels were not statistically sig...

The Role of AI-Generated Clinical Image Descriptions in Enhancing Teledermato...

Shapiro(J),Greenfield(B),Cohen(I),Dodiuk-G... Diagnostics (Basel) 2026-01-25

...Top1 (exact match), Top3 (correct within top three), Partial, or No match. Results: The study included 154 image descrip...

The reliability gap: Why high predictive accuracy doesn't guarantee stable fe...

Takefuji(Y) Mar Pollut Bull 2026-05-00

...top1-out procedure to test ranking stability. Random Forest and XGBoost with and without SHAP show pronounced instabilit...

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