Martin(S E),Wu(Z-H),Gehlhaus(K),Jones(T L)... Curr Cancer Drug Targets 2012-05-09

...Top1) poison camptothecin (CPT). Screening was conducted using a set of siRNAs corresponding to over 400 apoptosisrelate...

Watson(Venita Gresham),Hardison(Nicholas E... Mol Cancer Ther 2012-04-13

We have attempted to use a familial genetics strategy to study mechanisms of topoisomerase 1 (Top1) inhibition. Investig...

Kim(Nayun),Huang(Shar-yin N),Williams(Jess... Science 2011-07-06

...Top1, a topoisomerase that relaxes supercoils by reversibly nicking duplex DNA. The reported studies extend the role of ...

Kiselev(Evgeny),DeGuire(Sean),Morrell(Andr... J Med Chem 2011-10-31

A series of 7-azaindenoisoquinoline topoisomerase I (Top1) inhibitors have been prepared to investigate the effect of in...

Nishioka(Masanori),Shimada(Mitsuo),Kurita(... Cancer Genomics Proteomics 2011-07-22

...TOP1)), and cell proliferation (integrin, beta 1 (ITGB1))-related genes. In the immunohistochemistry of MMP7, 4 responde...

Gmeiner(William H),Salsbury(Freddie),Olsen... J Nucleic Acids 2011-11-10

...Top1 cleavage site inhibits DNA religation. The reduced efficiency for Top1-mediated religation contributes to the antic...

Laco(Gary S) PLoS One 2011-12-23

...Top1) relaxes supercoiled DNA during cell division. Camptothecin stabilizes Top1/dsDNA covalent complexes which ultimate...

Huang(Shar-yin N),Pommier(Yves),Marchand(C... Expert Opin Ther Pat 2011-11-23

...Top1) that result in stalled Top1 cleavage complexes (Top1cc) are commonly employed against cancer. Combination chemothe...

Kim(Nayun),Jinks-Robertson(Sue) DNA Repair (Amst) 2011-12-20

...Top1, possibly due to enhanced R-loop formation. Loss of Sgs1 helicase and RNase H activity also increased instability, ...

Ahowesso(Constance),Li(Xiao-Mei),Zampera(S... Chronobiol Int 2011-11-09

...Top1 were unchanged or down-regulated according to irinotecan timing and sex. This study shows that the circadian timing...