Conlon(Michael A),Kerr(Caroline A),McSween... J Nutr 2012-06-12

...Top1, Msh3, Ung, Rere, Cebpa, Gmnn, and Parg) was altered and varied with RS source. HAW is as effective as HAMS and HAM...

Zoppoli(Gabriele),Regairaz(Marie),Leo(Elis... Proc Natl Acad Sci U S A 2012-12-10

...Top1) inhibitors, a widely used class of DDAs. We assessed the NCI-60 transcriptome using Affymetrix Human Exon 1.0 ST m...

Chen(Allan Y),Chen(Patricia M T),Chen(Yi-Jen) J Thorac Dis 2012-08-30

...TOP1 drugs and radiotherapy offers a new frontier for lung cancer therapy. We review the present state of TOP1-targeted ...

Zeng(Zhihong),Sharma(Abhishek),Ju(Limei),M... Nucleic Acids Res 2012-12-18

...Top1) activity by hydrolyzing the 3'-phosphotyrosyl bond that links Top1 to a DNA strand break and is currently the only...

Sadek(Khaled Hassan),Cagampang(Felino Ramo... Fertil Steril 2012-12-10

...TOP1, UBC, EIF4A2, GAPDH, and B2M.,Hospital.,Female patients undergoing laparoscopic gynecological surgery were recruite...

Pourquier(P),Kohlhagen(G),Ueng(L M),Pommie... Methods Mol Med 2012-10-02

...top1 and top2 exhibit major differences concerning their mechanism of action. Top1 acts as a monomer and forms a covalen...

Honjo(Tasuku),Kobayashi(Maki),Begum(Nasim)... Adv Cancer Res 2012-07-20

...Top1) and a histone H3K4 epigenetic mark. When the level of Top1 protein is decreased by AID activation, it induces irre...

Nguyen(Trung Xuan),Morrell(Andrew),Conda-S... J Med Chem 2012-09-12

...Top1-Tdp1 inhibitors, which are based on the indenoisoquinoline chemotype. One bis(indenoisoquinoline) had significant a...

Kiselev(Evgeny),Empey(Nicholas),Agama(Keli... J Org Chem 2012-09-13

...Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that,...

Chen(Allan Y),Phan(Chau),Chang(Yi-Chieh),S... Discov Med 2012-10-02

...TOP1) are a novel class of anticancer agents with established activity against many cancers. In addition to their abilit...