Takagi(Motoki),Ueda(Jun-ya),Hwang(Ji-Hwan)... J Nat Prod 2012-07-20

...Top1)-DNA covalent complexes. Tdp1 inhibitors are regarded as potential cancer therapeutics in combination with Top1 inh...

Chen(Allan Y),Chen(Patricia M T),Chen(Yi-Jen) J Thorac Dis 2012-08-30

...TOP1 drugs and radiotherapy offers a new frontier for lung cancer therapy. We review the present state of TOP1-targeted ...

Zoppoli(Gabriele),Regairaz(Marie),Leo(Elis... Proc Natl Acad Sci U S A 2012-12-10

...Top1) inhibitors, a widely used class of DDAs. We assessed the NCI-60 transcriptome using Affymetrix Human Exon 1.0 ST m...

Zeng(Zhihong),Sharma(Abhishek),Ju(Limei),M... Nucleic Acids Res 2012-12-18

...Top1) activity by hydrolyzing the 3'-phosphotyrosyl bond that links Top1 to a DNA strand break and is currently the only...

Martin(S E),Wu(Z-H),Gehlhaus(K),Jones(T L)... Curr Cancer Drug Targets 2012-05-09

...Top1) poison camptothecin (CPT). Screening was conducted using a set of siRNAs corresponding to over 400 apoptosisrelate...

Kobayashi(Maki),Sabouri(Zahra),Sabouri(Som... Proc Natl Acad Sci U S A 2012-01-23

...Top1 is critical for SHM. Top1 knockdown or haploinsufficiency enhanced SHM, whereas Top1 overexpression down-regulated ...

Pourquier(Philippe),Lansiaux(Amélie) Bull Cancer 2012-01-10

...Top1 has been an attractive target for the development of anticancer drugs, which poison Top1 by trapping the enzyme on ...

Watson(Venita Gresham),Hardison(Nicholas E... Mol Cancer Ther 2012-04-13

We have attempted to use a familial genetics strategy to study mechanisms of topoisomerase 1 (Top1) inhibition. Investig...

Zhang(Xiaoyun),Wang(Rubing),Zhao(Li),Lu(Na... Bioorg Med Chem Lett 2012-08-24

...top1) inhibition. Among them, compound 25 was found to be 10-times more potent in cell-killing activity for both cell li...

Sacho(Elizabeth J),Maizels(Nancy) J Biol Chem 2012-02-27

...Top1) to the DNA backbone and that are the hallmark of damage caused by Top1 poisons such as camptothecin. Cleavage gene...