Tomicic(Maja T),Kaina(Bernd) Biochim Biophys Acta 2013-03-19

...TOP1 rests on inhibition of the re-ligation function of the enzyme resulting in the stabilization of the TOP1-cleavable ...

Dai(Tianli),Liu(Qi),Gao(Jun),Cao(Zhiwei),Z... BMC Bioinformatics 2013-03-08

...TOP1 candidates and TOP3 candidates in the ranking list, respectively, which performs better than those of SURFNET and P...

Kiritchenko(Svetlana),de Bruijn(Berry),Car... BMC Med Inform Decis Mak 2013-02-06

...top1 precision). Precision and recall of the extraction rules (second stage) were 93% and 91%, respectively. Together, t...

Cho(Jang-Eun),Kim(Nayun),Li(Yue C),Jinks-R... DNA Repair (Amst) 2013-08-07

...Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA. Top1 activity in...

Solier(Stéphanie),Ryan(Michael C),Martin(S... Cancer Res 2013-09-30

...Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and downstream of transcription comp...

Nguyen(Aurelia),Lasthaus(Christelle),Gueri... Cancers (Basel) 2013-11-12

...TOP1, TOP2A and TOP2B genes in 105 fresh-frozen diagnostic biopsies by allelotyping and real-time quantitative PCR. Our ...

Sakai(Akiko),Sakasai(Ryo),Kakeji(Yoshihiro... Genes Genet Syst 2013-06-18

...Top1)-DNA cleavage complexes induced by camptothecin (CPT) cause DNA strand breaks during DNA replication or transcripti...

Conda-Sheridan(Martin),Reddy(P V Narasimha... J Med Chem 2013-04-17

...Top1 inhibitors are of interest because the Top1 and Tdp1 inhibitory activities could theoretically work synergistically...

Cinelli(Maris A),Reddy(P V Narasimha),Lv(P... J Med Chem 2013-03-14

...Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent Top1 poi...

Taliani(Sabrina),Pugliesi(Isabella),Barres... J Med Chem 2013-11-26

In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, st...