Solier(Stéphanie),Ryan(Michael C),Martin(S... Cancer Res 2013-09-30

...Top1) relaxes DNA supercoiling by forming transient cleavage complexes (Top1cc) up- and downstream of transcription comp...

D'Souza(Ursula M),Powell-Smith(Georgia),Ha... Am J Med Genet B Neuropsych... 2013-10-17

...TOP1) genes were found to be the most stably expressed housekeeping genes in drug-treated LCLs. Subsequently, quantitati...

King(Ian F),Yandava(Chandri N),Mabb(Angela... Nature 2013-12-11

...TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including n...

Taliani(Sabrina),Pugliesi(Isabella),Barres... J Med Chem 2013-11-26

In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, st...

Cho(Jang-Eun),Kim(Nayun),Li(Yue C),Jinks-R... DNA Repair (Amst) 2013-08-07

...Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA. Top1 activity in...

Norman-Axelsson(Ulrika),Durand-Dubief(Mick... PLoS Genet 2013-06-13

...Top1 and Top2, is highly enriched at centromeric central domains, demonstrating that Top3 is the major topoisomerase in ...

Smith(David Hersi),Christensen(Ib Jarle),J... PLoS One 2013-10-22

...Top1) is the target of Top1 inhibitor chemotherapy. The TOP1 gene, located at 20q12-q13.1, is frequently detected at ele...

Sakai(Akiko),Sakasai(Ryo),Kakeji(Yoshihiro... Genes Genet Syst 2013-06-18

...Top1)-DNA cleavage complexes induced by camptothecin (CPT) cause DNA strand breaks during DNA replication or transcripti...

Lin(Ren-Kuo),Ho(Chia-Wen),Liu(Leroy F),Lyu... J Biol Chem 2013-04-30

...Top1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing replication forks. ...

Cinelli(Maris A),Reddy(P V Narasimha),Lv(P... J Med Chem 2013-03-14

...Top1) inhibitors indotecan (LMP400) and indimitecan (LMP776) have been prepared because (1) a variety of potent Top1 poi...