Tentori(Lucio),Leonetti(Carlo),Muzi(Alessi... Int J Oncol 2014-01-07

...Top1) inhibitors against a variety of cancers, including colon carcinoma. Since the mismatch repair component MLH1 is de...

Arnò(Barbara),Coletta(Andrea),Tesauro(Cinz... Biosci Rep 2014-09-04

...Top1 (topoisomerase I) catalytic cycle have been analysed in the presence of a pentacyclic-diquinoid synthetic compound....

Rolle(Cleo E),Kanteti(Rajani),Surati(Mosmi... Mol Cancer Ther 2014-11-12

...Top1 using 7-ethyl-10-hydroxycamptothecin (SN-38). MET and TOP1 gene copy numbers and protein expression were determined...

Alagoz(Meryem),Wells(Owen S),El-Khamisy(Sh... Nucleic Acids Res 2014-05-19

...Top1, illustrating that alkylating agents can trigger cytotoxic Top1-breaks. Although inhibition of PARP activity does n...

Katyal(Sachin),Lee(Youngsoo),Nitiss(Karin ... Nat Neurosci 2014-08-04

...Top1cc formation and excessive DNA damage and neurodevelopmental defects. Notably, direct Top1 poisoning to elevate Top1...

Dalla Rosa(Ilaria),Huang(Shar-Yin N),Agama... J Biol Chem 2014-10-16

...Top1mt cleavage complexes (Top1mtcc) can be stabilized in vitro by camptothecin (CPT). However, CPT does not trap Top1mt...

Lv(Peng-Cheng),Agama(Keli),Marchand(Christ... J Med Chem 2014-08-08

...Top1 inhibitors and thereby potentiate the effects of Top1 poisons. This study describes the successful design and synth...

Tsakalozou(Eleftheria),Adane(Eyob D),Liang... Cancer Chemother Pharmacol 2014-09-26

...Top1), γH2AX, caspase 3 and PARP protein content was evaluated. AR-67 plasma and tumor pharmacokinetics were also studie...

Kiianitsa(Kostantin),Maizels(Nancy) Nucleic Acids Res 2014-10-14

...Top1-DNA and Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Escherichia coli. This approach will be useful ...

Li(Fengzhi) Am J Cancer Res 2014-06-24

...Top1) inhibitors for cancer treatment, cancer cells with Top1 mutations shows little contributions of treatment resistan...