Kiianitsa(Kostantin),Maizels(Nancy) Nucleic Acids Res 2014-10-14

...Top1-DNA and Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Escherichia coli. This approach will be useful ...

Kim(Nayun),Cho(Jang-Eun),Li(Yue C),Jinks-R... PLoS Genet 2014-05-14

...Top1 activity. QP mutation rates are strongly affected by the direction of DNA replication and, in contrast to their ele...

Hütter(Gero),Blüthgen(Christian),Neumann(M... AIDS Res Ther 2014-01-16

...TOP1, CXCR2, SREBF2, and TAP we found a different regulation which was consistent with a supposed beneficial effect for ...

Bertozzi(Davide),Marinello(Jessica),Manzo(... Mol Cancer Ther 2014-09-29

DNA topoisomerase I (Top1) inhibition by camptothecin derivatives can impair the hypoxia-induced cell transcriptional re...

Nygård(Sune Boris),Christensen(Ib Jarle),N... Scand J Gastroenterol 2014-09-19

...TOP1 was identified in 52.6% and 37.2% using the following cutoff values: TOP1 signal count per cell ≥3.6 and TOP1/CEN-2...

Rolle(Cleo E),Kanteti(Rajani),Surati(Mosmi... Mol Cancer Ther 2014-11-12

...Top1 using 7-ethyl-10-hydroxycamptothecin (SN-38). MET and TOP1 gene copy numbers and protein expression were determined...

Allen-Soltero(Stephanie),Martinez(Sandra L... Mol Cell Biol 2014-05-21

...TOP1 suppressed the increased GCR rates and/or the growth defects of rnh203Δ double mutants. This analysis suggests that...

Beck(Daniel E),Agama(Keli),Marchand(Christ... J Med Chem 2014-04-29

...Top1) inhibitor class to the indenoisoquinoline system in search of structurally novel and potent Top1 inhibitors. The s...

Gao(Rui),Das(Benu Brata),Chatterjee(Raghun... DNA Repair (Amst) 2014-07-23

...Top1) cleavage complexes (Top1cc). It also removes 3'-blocking residues derived from oxidative damage or incorporation o...

Gmeiner(William H),Lema-Tome(Carla),Gibo(D... J Neurooncol 2014-09-23

...Top1) cleavage complex formation were evaluated using TS activity assays and in vivo complex of enzyme bioassays. Cytoto...