Takacova(T),Schirmer(MA) Front Pharmacol None

...TOP1, TOP2A, TOP2B, TOP3A, and TOP3B, 1,126 polymorphic sites were identified, with 468 at a minor allele frequency (MAF...

Saha(S),Dhall(A),Huang(SN),Saha(LK),Al Mah... iScience 2026-09-18

...TOP1-depleted cells demonstrates partially overlapping and complementary functions of TOP3B and topoisomerase 1 (TOP1) i...

Tsypyshev(D),Khomenko(T),Kornienko(T),Zakh... Int J Mol Sci 2026-07-19

...TOP1) inhibitors, a major class of clinically relevant antineoplastic drugs. This paper describes the design and synthes...

Mazahreh(RC),Lim(CB),Garcia(NH),Olson(DJ),... Mol Cancer Ther 2026-07-28

...TOP1) inhibitor, AMDCPT, using a traceless enzyme-cleavable glucuronide linker. The AMDCPT payload has been optimized fo...

Hu(DX),Qin(C),Gao(X),Tang(L),Zheng(Y),Yin(... J Enzyme Inhib Med Chem 2026-12-00

...TOP1 inhibition (+++) and induced the formation of cellular TOP1 cleavage complexes (TOP1cc) and DNA damage, and consequ...

Qian(C),Yang(Z),Xu(X),Dang(K),Dong(Q),Yu(H... J Mol Cell Biol 2026-08-19

...Top1) is essential for the initiation of biliary-derived liver regeneration. Top1 upregulation occurred early after live...

Dos Santos(CS),Magalhães(AC),Fernandes(V),... Cancers (Basel) 2026-07-30

...TOP1 inhibitor, while being equally sensitive to epirubicin hydrochloride, a TOP2 inhibitor. The cardiac glycoside digox...

Zeng(H),Zhang(M),Qiu(B),Zhang(S),Liu(J),Lu... RSC Adv 2026-08-12

...TOP1)-mediated DNA damage and is a promising anticancer target, particularly in combination with TOP1 inhibitors. Howeve...

Huang(Z),Xiang(L),Tang(D),Dai(Y) Mol Biol Rep 2026-08-13

...TOP1, POLD1/POLD3, and ATR, while distinguishing them from emerging mechanisms requiring CRC-specific validation. We als...

Murugan(D),Rangasamy(L) Bioconjug Chem 2026-08-19

...Top1 inhibitor, via the Fol-SS-Exa (8) conjugate, demonstrating its potency against FR-positive cancer cells in vitro an...