Steinacher(Roland),Osman(Fekret),Lorenz(Al... PLoS One 2014-04-01

...Top1) cleavage complexes and removal of toxic SUMO conjugates. We show that it is the latter function that constitutes S...

Chen(Stefanie Hartman),Plank(Jody L),Willc... PLoS One 2014-11-18

...Top1 (in place of Top3α), we show that the presence of a topoisomerase is required for Blm to substantially migrate a to...

Mikulová(Veronika),Cabiňaková(Michaela),Ja... Scand J Clin Lab Invest 2014-11-03

...TOP1, TOP2A, CTSD, ST6, CK19 and reference gene actin.,We found that CTCs can be detected in the peripheral blood of app...

Gao(Rui),Das(Benu Brata),Chatterjee(Raghun... DNA Repair (Amst) 2014-07-23

...Top1) cleavage complexes (Top1cc). It also removes 3'-blocking residues derived from oxidative damage or incorporation o...

Gmeiner(William H),Lema-Tome(Carla),Gibo(D... J Neurooncol 2014-09-23

...Top1) cleavage complex formation were evaluated using TS activity assays and in vivo complex of enzyme bioassays. Cytoto...

Stenvang(Jan),Kümler(Iben),Nygård(Sune Bor... Front Oncol 2014-06-24

...Top1) inhibitors and Top1 as a potential predictive biomarker as case in point.

Walker(Sarah),Meisenberg(Cornelia),Bibby(R... Anal Biochem 2014-12-03

...TOP1 with DNA via a tyrosine residue. This reversible TOP1-cleavage complex intermediate can become trapped on DNA by TO...

Kiselev(Evgeny),Sooryakumar(Dhriti),Agama(... J Med Chem 2014-04-29

...Top1 inhibitory potencies and cancer cell cytotoxicities. The new compounds 14-17 and 19 exhibited mean graph midpoint c...

Macleod(A M),Ferroni(G D),Unrau(P) World J Microbiol Biotechno... 2014-01-15

...top1-1) of S. cerevisiae yielded tetracycline-resistant recombinants, as did a temperature-sensitive double mutant (top2...

Das(Benu Brata),Huang(Shar-yin N),Murai(Ju... Nucleic Acids Res 2014-07-08

...Top1 cleavage complexes (Top1cc) that are trapped by the drugs. Endogenous and carcinogenic DNA lesions can also trap To...