Jossé(Rozenn),Martin(Scott E),Guha(Rajarsh... Cancer Res 2015-03-04

Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent an...

Mabb(Angela M),Kullmann(Paul H M),Twomey(M... Proc Natl Acad Sci U S A 2015-04-28

Topotecan is a topoisomerase 1 (TOP1) inhibitor that is used to treat various forms of cancer. We recently found that to...

Wang(W-L),Huang(H-C),Kao(S-H),Hsu(Y-C),Wan... Oncogene 2015-04-24

...TOP1, DNA Ligase IV and Rad17, reduces cell proliferation, delays S-phase progression and contributes to genome instabil...

Arakawa(Yasuhiro),Ozaki(Koji),Okawa(Yutaka... Oncol Rep 2014-06-12

...Top1 Gly717Arg mutation and some had also a Top1 Gln421Arg mutation. Top1 activity was reduced to approximately one-eigh...

Wilson(Colin R),Fagenson(Alexander M),Ruan... Inorg Chem 2014-02-07

...Top1) poisons camptothecin and 9-methoxycamptothecin. The Top2-catalyzed decatenation reaction of kinetoplast DNA was st...

Wang(Ning),Zhu(Meifen),Tsao(Sai-Wah),Man(K... Mol Cancer 2014-07-08

...TOP1) is down-regulated in miR-23a-overexpressed HCC cells. MiR-23a could directly bind to 3'untranslated region of TOP1...

Saikia(Nabanita),Deka(Ramesh C) J Comput Aided Mol Des 2014-05-22

...Top1 protein.

Maede(Yuko),Shimizu(Hiroyasu),Fukushima(To... Mol Cancer Ther 2014-09-29

...Top1 inhibitors as well as Top2 inhibitors, whereas the profiles of Top1 inhibitors were different from those of Top2 in...

Moreau(Magali),Westlake(Timothy),Zampogna(... Plant J 2014-06-09

...TOP1 and TOP2 mediate SA-dependent signaling and are necessary for the immune response to avirulent pathogens. Our resul...

Siu(Fung-Ming),Pommier(Yves) Nucleic Acids Res 2014-02-13

...Top1) inhibitors, such as camptothecin (CPT), stabilize the Top1-DNA cleavage complex in a DNA sequence-dependent manner...