3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. T...
...TOP1 catalysis. TOP1 is the target of chemotherapeutic drugs of the camptothecin family (CPT). TDP1 has in cell line bas...
...Top1 share a common reaction mechanism and domain structure. However, the human Top1 is ∼100-fold more sensitive to CPT....
...TOP1, which was consistent with the docking analysis results. We performed a 3D-QSAR study using CoMFA and CoMSIA to det...
...TOP1; Topotecan, Irinotecan) and targeted therapies including inhibitors of histone deacetylases (HDAC; Panobinostat) an...
...Top1-cc accumulation. Top1-cc could be a risk factor for neurodegeneration as they may interfere with transcription elon...
...Top1-DNA adducts. Meanwhile, Pxd1 attenuates DNA end resection mediated by the Rqh1-Dna2 pathway. Disabling the Dna2-inh...
...TOP1, CYC1 and YWHAZ in placenta does not significantly alter between these cohorts, or across gestation.
...Top1 inhibitors as an effective therapeutic strategy in treating tumors that expresses Gli1.
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