Pedersen(Mette Ø),Poulsen(Tim S),Gang(Anne... Exp Hematol 2015-08-31

...TOP1 and TOP2A gene alterations were investigated in patients with de novo diffuse large B-cell lymphoma (DLBCL) (n = 33...

Takahata(Chiaki),Masuda(Yuji),Takedachi(Ar... Carcinogenesis 2015-10-19

...Top1) is the intercellular target of camptothecins (CPTs). CPT blocks DNA religation in the Top1-DNA complex and induces...

Meisenberg(Cornelia),Gilbert(Duncan C),Cha... Mol Cancer Ther 2015-11-03

...TOP1) poison irinotecan, which triggers cell death by trapping TOP1 on DNA. The removal of TOP1 peptide from TOP1-DNA br...

Alonso(Concepción),Fuertes(María),González... Curr Top Med Chem 2015-09-21

...Top1 and antiproliferative activity against human colon cancer cells (COLO 205).

Puc(Janusz),Kozbial(Piotr),Li(Wenbo),Tan(Y... Cell 2015-04-24

...TOP1) to a large cohort of AR-regulated enhancers. Furthermore, we show that the DNA nicking activity of TOP1 is a prere...

Grunnet(Mie),Calatayud(Dan),Schultz(Nicola... Scand J Gastroenterol 2015-12-04

...TOP1 copy number and 6.4% had a TOP1/CEN-20 ratio >1.5. Neither the TOP1 copy number nor the TOP1/CEN-20 ratios could pr...

Jakobsen(Ann-Katrine),Lauridsen(Kristina L... Exp Mol Pathol 2015-10-05

...TOP1 catalysis. TOP1 is the target of chemotherapeutic drugs of the camptothecin family (CPT). TDP1 has in cell line bas...

Azevedo(Cristina),Livermore(Thomas),Saiard... Mol Cell 2015-06-08

...Top1 interaction and impairs Top1 enzymatic activity. Physiological modulation of cellular levels of polyP regulates Top...

Nguyen(Trung Xuan),Abdelmalak(Monica),Marc... J Med Chem 2015-06-30

...Top1-TDP1 inhibition. The 9-hydroxy series exhibited potencies and cytotoxicities vs Top1 that surpassed those of campto...

Akerman(Kate J),Fagenson(Alexander M),Cyri... J Am Chem Soc 2015-05-11

...Top1. Two pivotal enzyme inhibition assays prove that the compounds are true catalytic inhibitors of Top1. Inhibition of...