Qiu(Jin),Zhao(Baobing),Zhong(Wanxia),Shen(... Eur J Med Chem 2015-12-28

...TOP1, which was consistent with the docking analysis results. We performed a 3D-QSAR study using CoMFA and CoMSIA to det...

Beck(Daniel E),Abdelmalak(Monica),Lv(Wei),... J Med Chem 2015-08-06

3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. T...

Yin(Lianhong),Zheng(Lingli),Xu(Lina),Dong(... BMC Complement Altern Med 2015-10-22

...TOP1 inhibitor, which can treat cancer though the cell cycle- transition and termination of DNA replication pathway. Dio...

Huang(Shar-Yin Naomi),Ghosh(Sanchari),Pomm... J Biol Chem 2015-08-18

...Top1-induced nicks. We demonstrate that a second Top1 cleavage complex adjacent to the nick and subsequent faulty Top1 r...

Sparks(Justin L),Burgers(Peter M) EMBO J 2015-07-22

...Top1) by either error-free or mutagenic repair. Here, we present a biochemical analysis of these pathways. Top1 cleavage...

Maul(Robert W),Saribasak(Huseyin),Cao(Zhen... DNA Repair (Amst) 2015-09-04

...Top1), which relaxes DNA supercoiling in front of the transcription complex. Top1 was decreased by stable transfection o...

Kümler(Iben),Balslev(Eva),Poulsen(Tim S),N... Int J Cancer 2015-11-24

...Top1 inhibitors in BC. The aim was to determine the prevalence of TOP1 gene copy gain in BC. The prevalence of TOP1 gene...

Williams(Jessica S),Clausen(Anders R),Luja... Nat Struct Mol Biol 2015-07-02

...Top1) incises DNA at unrepaired ribonucleotides, initiating their removal, but this is accompanied by RNA-DNA-damage phe...

Tao(Cui),Sun(Jingchun),Zheng(W Jim),Chen(J... Database (Oxford) 2015-09-18

...TOP1 and VEGFA are known targets of FDA-approved drugs. Additionally, CCND1 (cyclin D1), and PTGS2 (prostaglandin-endope...

Westlake(Timothy J),Ricci(William A),Popes... Front Plant Sci 2015-06-04

...TOP1 and TOP2. Altogether, our work indicates that TOP1 and TOP2 mediate plant responses to oxidative stress through spa...